慢性乙型肝炎的血清乙型肝炎病毒核糖核酸及其影响因素

StephenW

Serum hepatitis B virus ribonucleic acid and its influencing factors in chronic hepatitis B
Yifeng Zhou  1 , Yameng Peng  1 , Hao Yuan  1 , Zhenyi Long  1 , Sixian Wu  1 , Jiping Yang  1
Affiliations
Affiliation

    1
    Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.

    PMID: 33928768 DOI: 10.17219/acem/131756

Abstract

Background: Hepatitis B virus (HBV) remains one of the most serious and prevalent health problems in the world.

Objectives: To determine the serum hepatitis B virus (HBV) RNA levels in patients with chronic hepatitis B (CHB) with low HBV DNA levels and analyze the influencing factors.

Material and methods: Seventy-two CHB patients with low HBV DNA levels were enrolled and divided into 2 groups according to hepatitis B e antigen (HBeAg) status; their age, sex, the incidence of HBV RNA level < lower limit of detection (LLD), and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), quantitative determination of HBsAg (qHBsAg), HBV DNA, and HBV RNA levels were compared. The factors influencing serum HBV RNA levels < LLD and the correlation between serum HBV RNA levels, and serum ALT, AST, qHBsAg and HBV DNA levels were analyzed.

Results: In HBeAg-positive patients, serum AST, qHBsAg and HBV RNA levels were higher, and serum HBV DNA levels and incidence of HBV RNA < LLD were lower than those in HBeAg-negative patients (p < 0.05). Multivariate linear regression analysis revealed that HBeAg is a factor that significantly influences serum HBV RNA levels in patients with CHB (p < 0.05). Multivariate logistic regression analysis indicated that HBeAg and qHBsAg are factors that influence serum HBV RNA levels < LLD in patients with CHB. In HBeAg-positive patients, serum HBV RNA levels were positively correlated with qHBsAg and HBeAg.

Conclusions: The serum HBV RNA levels in CHB patients with low HBV DNA levels varied according to HBeAg status. The HBeAg is a factor that significantly influences serum HBV RNA levels in patients with CHB, while HBeAg and qHBsAg are factors that significantly influence serum HBV RNA levels < LLD in patients with CHB.

Keywords: DNA; chronic hepatitis B; hepatitis B virus; pre-gene RNA; serum markers.

StephenW

慢性乙型肝炎的血清乙型肝炎病毒核糖核酸及其影响因素
周以锋1，彭亚萌1，郝元1，龙振一1，吴思贤1，杨继平1
隶属关系
联系

    1个
    湖南省人民医院，湖南师范大学第一附属医院，长沙

    PMID：33928768 DOI：10.17219 / acem / 131756

抽象的

背景：乙型肝炎病毒（HBV）仍然是世界上最严重，最普遍的健康问题之一。

目的：确定低HBV DNA水平的慢性乙型肝炎（CHB）患者的血清乙肝病毒（HBV）RNA水平，并分析其影响因素。

资料与方法：纳入72例HBV DNA水平低的CHB患者，根据乙型肝炎e抗原（HBeAg）状况分为两组。他们的年龄，性别，HBV RNA水平的发生率<检测下限（LLD）和血清丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），定量测定HBsAg（qHBsAg），HBV DNA和HBV RNA水平比较的。分析了影响血清HBV RNA水平<LLD的因素以及血清HBV RNA水平与血清​​ALT，AST，qHBsAg和HBV DNA水平的相关性。

结果：HBeAg阳性患者的血清AST，qHBsAg和HBV RNA水平较高，血清HBV DNA水平和HBV RNA <LLD的发生率低于HBeAg阴性患者（p <0.05）。多元线性回归分析显示，HBeAg是影响CHB患者血清HBV RNA水平的重要因素（p <0.05）。多元logistic回归分析表明，HBeAg和qHBsAg是影响CHB患者血清HBV RNA水平<LLD的因素。在HBeAg阳性患者中，血清HBV RNA水平与qHBsAg和HBeAg呈正相关。

结论：低HBV DNA水平的CHB患者血清HBV RNA水平随HBeAg状态的不同而不同。 HBeAg是显着影响CHB患者血清HBV RNA水平的因素，而HBeAg和qHBsAg是显着影响CHB患者血清HBV RNA水平<LLD的因素。

关键字：DNA；慢性乙型肝炎乙型肝炎病毒;前基因RNA；血清标志物。