肝癌切除术中血清阿尔法甲胎蛋白和血清Des-γ-羧基凝血酶的

StephenW

Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma
Masamichi Hayashi  1 , Suguru Yamada  2 , Nao Takano  1 , Yukiyasu Okamura  3 , Hideki Takami  1 , Yoshikuni Inokawa  1 , Fuminori Sonohara  1 , Nobutake Tanaka  1 , Dai Shimizu  1 , Norifumi Hattori  1 , Mitsuro Kanda  1 , Chie Tanaka  1 , Goro Nakayama  1 , Masahiko Koike  1 , Yasuhiro Kodera  1
Affiliations
Affiliations

    1
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    2
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan; [email protected].
    3
    Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

    PMID: 33910859 DOI: 10.21873/invivo.12434

Abstract

Background/aim: Hepatocellular carcinoma (HCC) mainly develops in the damaged liver from hepatitis C virus (HCV) or hepatitis B virus (HBV) infection in Japan. On the other hand, the occurrence of HCCs derived from the liver without viral infection has recently been increasing. Our aim was to identify characteristics specific to HCCs with virus-infected liver (HCC-BC) or those with non-B- and non-C-infected liver (HCC-NBNC), Patients and Methods: We collected preoperative serum α-fetoprotein (AFP) and Des-Gamma-Carboxy Prothrombin (DCP), also known as PIVKA-II values from surgically resected HCC cases during 1994-2017 in our department.

Results: Preoperative serum AFP values of HCC-BC cases (n=284) were higher compared to HCC-NBNC cases (n=88) (p=0.016), whereas serum DCP values of HCC-NBNC cases were higher compared to HCC-BC cases (p<0.001). Multivariable analyses indicated that abnormal serum AFP [hazard ratio (HR)=1.46, 95% conficdence interval (CI)=1.03-2.07, p=0.035) was one of the significant recurrence-free survival predictors of HCC-BC cases, while abnormal serum DCP (HR=4.99, 95%CI=1.91-13.01, p=0.001) was one of the significant recurrence-free survival predictors of HCC-NBNC cases.

Conclusion: HCC-NBNC cases have a different tumor marker profile from HCC-BC cases. Elevated DCP could be both a diagnostic and prognostic marker of HCC-NBNC patients.

Keywords: AFP; DCP; hepatocellular carcinoma; survival predictor.

Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

StephenW

肝癌切除术中血清阿尔法甲胎蛋白和血清Des-γ-羧基凝血酶的不同特征
林正美1，山田S 2，高野直1，冈村行康3，高见秀1，井上义国1，富野森里1，田中信武1，大清水1，服部典夫1，三田关代1，千田千惠1，中山五郎1，小池雅彦1，小田康宏1
隶属关系
隶属关系

    1个
    名古屋大学医学研究科胃肠病外科，日本名古屋。
    2个
    名古屋大学大学院医学系胃肠外科，日本名古屋； [email protected]。
    3
    日本静冈静冈癌症中心肝胆胰外科。

    PMID：33910859 DOI：10.21873 / invivo.12434

抽象的

背景/目的：在日本，丙型肝炎病毒（HCV）或乙型肝炎病毒（HBV）感染主要在受损的肝脏中发展肝细胞癌（HCC）。另一方面，无病毒感染的源自肝的HCC的发生最近在增加。我们的目的是确定病毒感染的肝癌（HCC-BC）或非B和非C感染的肝癌（HCC-NBNC）的肝癌特有的特征。患者和方法：我们收集了术前血清甲胎蛋白（AFP）和Des-Gamma-Carboxy Prothrombin（DCP）（也称为PIVKA-II值）来自我科1994-2017年间经手术切除的HCC病例。

结果：HCC-BC病例（n = 284）的术前血清AFP值高于HCC-NBNC病例（n = 88）（p = 0.016），而HCC-NBNC病例的血清DCP值高于HCC-NBNC病例。 BC病例（p <0.001）。多变量分析表明，血清AFP异常[危险比（HR）= 1.46，95％置信区间（CI）= 1.03-2.07，p = 0.035）是HCC-BC患者无复发的重要预后指标之一，而异常血清DCP（HR = 4.99，95％CI = 1.91-13.01，p = 0.001）是HCC-NBNC病例的重要的无复发生存预测指标之一。

结论：HCC-NBNC病例与HCC-BC病例具有不同的肿瘤标志物谱。 DCP升高可能是HCC-NBNC患者的诊断和预后指标。

关键字：法新社； DCP;肝细胞癌；生存预测指标。

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