灰区慢性乙型肝炎病毒感染患者的分布及临床特征

StephenW

Distribution and clinical characteristics of patients with chronic hepatitis B virus infection in the grey zone
Yao K, Liu J, Wang J, et al
Journal of Viral Hepatitis|April 28, 2021
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Journal Summary

In this study, the distribution and characteristics of ‘grey zone (GZ)’ in a large cohort of chronic hepatitis B (CHB) patients were explored. Researchers included a total of 4,759 consecutive treatment‐naïve CHB patients. In this analysis, distributions of different immune states included 233 (4.90%) patients in the immune‐tolerant phase, 941 (19.77%) patients in the HBeAg‐positive immune active phase, 1,717 (36.08%) patients in the inactive phase, and 546 (11.47%) patients in HBeAg‐negative immune active phase. The outcomes of this research demonstrate that more than a quarter of CHB individuals were divided into the GZ and a high proportion of individuals in GZ‐B had advanced fibrosis or even cirrhosis.

StephenW

灰区慢性乙型肝炎病毒感染患者的分布及临床特征
姚K，刘J，王J等
病毒性肝炎杂志| 2021年4月28日
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期刊摘要

在这项研究中，我们探讨了一大群慢性乙型肝炎（CHB）患者的“灰色区（GZ）”的分布和特征。 研究人员总共包括4759名连续接受过首次治疗的CHB患者。 在此分析中，不同免疫状态的分布包括免疫耐受期的233名患者（4.90％），HBeAg阳性免疫活性期的941名患者（19.77％），非活性期的1,717名（36.08％）患者和 546（11.47％）位处于HBeAg阴性免疫活性期的患者。 这项研究的结果表明，超过四分之一的CHB个体被分为GZ，而GZ-B中有很大比例的个体患有晚期纤维化甚至肝硬化。

StephenW

https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvh.13511