评估泰国慢性乙型肝炎患者预测肝细胞癌的风险评分

StephenW

Assessing Risk Scores for Predicting Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B
Thanachote Kamalapirat  1 , Kesinee Yingcharoen  2 , Teerapat Ungtrakul  1 , Kamonwan Soonklang  3 , Jiraporn Dechma  2 , Pitchayachuda Chunnuan  2 , Pattama Kusuman  2 , Charinthip Pothijaroen  2 , Jantarika Tawpa  2 , Kunsuda Cheirsilpa  2 , Chirayu Auewarakul  1
Affiliations
Affiliations

    1
    Faculty of Medicine and Public Health, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.
    2
    Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.
    3
    Data Management Unit, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand.

    PMID: 33880807 DOI: 10.1111/jvh.13517

Abstract

Chronic hepatitis B (CHB) infection-associated hepatocellular carcinoma (HCC) is a major health problem in Asian countries. Several HCC risk prediction models have been developed using either treated or untreated CHB patients. However, there is limited validation of these risk scores in a treated and untreated mixed CHB patient cohort. This study analyzed and validated HCC risk scores among 2,208 CHB patients who enrolled in the HCC surveillance program in Thailand during July 2010. The baseline clinical and radiologic data of these CHB patients were applied to calculate various HCC risk scores. There were 20 patients (0.9%) with HCC development at the 5.9-year follow-up. The areas under the receiver operating characteristic curves (AUROCs) predicting HCC risk at 5 years were 0.80 (0.68-0.91), 0.73 (0.60-0.85), 0.79 (0.67-0.91), 0.70 (0.58-0.82), 0.72 (0.59-0.85), 0.76 (0.63-0.87, and 0.77 (0.64-0.89) for the GAG-HCC, CU-HCC, REACH-B, PAGE-B, mPAGE-B, CAMD, and AASL scores, respectively. The overall HCC risk scores were accurate and comparable. However, the subgroup analysis revealed better HCC-risk-predictive performance in the treated patients while performance was less helpful in those not fulfilling criteria for antiviral therapy. Clinicians should be aware of these data when using the HCC risk score in untreated CHB patients.

Keywords: Assess; Chronic Hepatitis B; Hepatocellular Carcinoma; Prediction Risk Score.

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StephenW

评估泰国慢性乙型肝炎患者预测肝细胞癌的风险评分
Thanachote Kamalapirat 1，Kesinee Yingcharoen 2，Teerapat Ungtrakul 1，Kamonwan Soonklang 3，Jiraporn Dechma 2，Pitchayachuda Chunnuan 2，Pattama Kusuman 2，Charinthip Pothijaroen 2，Jantarika Tawpa 2，Kunsuda Cheirsilpa 2，Chirayu Aue
隶属关系
隶属关系

    1个
    泰国曼谷Chulabhorn皇家学院Chulabhorn公主医学学院，HRH公主医学院。
    2个
    泰国曼谷Chulabhorn皇家学院Chulabhorn公主医学院的Chulabhorn医院，Churabhorn医院。
    3
    泰国曼谷Chulabhorn皇家学院Chulabhorn公主医学学院HRH数据管理部门。

    PMID：33880807 DOI：10.1111 / jvh.13517

抽象的

慢性乙型肝炎（CHB）感染相关的肝细胞癌（HCC）是亚洲国家的主要健康问题。使用已治疗或未治疗的CHB患者，已经开发了几种HCC风险预测模型。但是，在已治疗和未治疗的混合型CHB患者队列中，对这些风险评分的验证有限。本研究分析并验证了2010年7月在泰国参加HCC监测计划的2208名CHB患者的HCC风险评分。这些CHB患者的基线临床和放射学数据用于计算各种HCC风险评分。在5.9年的随访中，有20例（0.9％）HCC发生。可以预测5年HCC风险的接收器工作特征曲线（AUROC）下面积分别为0.80（0.68-0.91），0.73（0.60-0.85），0.79（0.67-0.91），0.70（0.58-0.82），0.72（0.59- GAG-HCC，CU-HCC，REACH-B，PAGE-B，mPAGE-B，CAMD和AASL评分分别为0.85、0.76（0.63-0.87和0.77（0.64-0.89）。分数是准确的和可比较的，但是，亚组分析显示，接受治疗的患者具有更好的HCC风险预测性能，而对于那些未达到抗病毒治疗标准的患者，性能降低的帮助较小。在未经治疗的CHB患者中。

关键字：评估；慢性乙型肝炎；肝细胞癌；预测风险评分。

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