FibroScan測試在ALT <2正常上限的HBV患者的抗病毒治療中的

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Effect of FibroScan test in antiviral therapy for HBV-infected patients with ALT <2 upper limit of normal
Xian-Zhi Han  1 , Shu-Feng Zhang  1 , Jia-Yin Yi  1 , Bin Wang  1 , Hui-Qing Sun  1
Affiliations
Affiliation

    1
    Department of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

    PMID: 33817230 PMCID: PMC7874573 DOI: 10.1515/biol-2020-0044

Abstract

Objective: The objective of this study is to detect the liver stiffness of hepatitis B virus (HBV)-infected patients with an alanine aminotransferase (ALT) level of <2 upper limit of normal (2ULN) by FibroScan and compare histological changes to assess the progression of liver lesions and its test results.

Methods: There were 36 patients who had a liver FibroScan degree of >7.3 KD (F1), and a liver biopsy was conducted. Along with serology of liver fibrosis, indexes and hierarchical processing were used for evaluation. The correlation between these factors was analyzed.

Results: The histopathological results of the liver were closely correlated with liver hardness. In the pathological diagnosis of chronic hepatitis, G represents the grade of inflammation and S represents the stage of hepatic fibrosis. Pathological examination results of H&E staining of liver tissue sections revealed that the area under the work characteristic curve of the subjects in G2S1, G2S2, G3S2, and G3S3 stages was 0.923, 0.916, 0.955, and 0.971, respectively, with diagnostic cut-off values of 9.03, 9.85, 15.14, and 30.67, respectively. Furthermore, hydroxyapatite, type III procollagen, laminin, and type IV collagen of serum fibrosis indexes are associated with liver stiffness values (P < 0.05).

Conclusion: FibroScan can be used as an alternative to liver biopsy. It is meaningful in determining whether HBV infected patients with an ALT level of <2 ULN should receive antiviral therapy.

Keywords: ALT <2 ULN; FibroScan; HBV infection; antiviral therapy opportunity.

© 2020 Xian-Zhi Han et al., published by De Gruyter.

StephenW

FibroScan測試在ALT <2正常上限的HBV感染患者的抗病毒治療中的作用
韓賢志1，張書峰1，易佳音1，王斌1，孫慧清1
隸屬關係
聯繫

    1個
    鄭州大學第五附屬醫院消化內科，鄭州450052

    PMID：33817230 PMCID：PMC7874573 DOI：10.1515 / biol-2020-0044

抽象的

目的：本研究的目的是通過FibroScan檢測丙型肝炎病毒（HBV）感染的丙氨酸轉氨酶（ALT）水平低於正常值上限（2ULN）上限2的患者的肝硬度，並比較組織學變化以評估肝髒病變的進展及其測試結果。

方法：36例肝纖維化掃描> 7.3 KD（F1），並進行了肝活檢。除肝纖維化血清學檢查外，還使用指標和分級處理進行評估。分析了這些因素之間的相關性。

結果：肝臟的組織病理學結果與肝臟硬度密切相關。在慢性肝炎的病理診斷中，G代表炎症的程度，S代表肝纖維化的階段。肝組織切片H＆E染色的病理檢查結果顯示，受試者的工作特徵曲線下處於G2S1，G2S2，G3S2和G3S3階段的面積分別為0.923、0.916、0.955和0.971，診斷閾值為分別為9.03、9.85、15.14和30.67。此外，血清纖維化指數的羥磷灰石，III型膠原蛋白，層粘連蛋白和IV型膠原蛋白與肝硬度值相關（P <0.05）。

結論：FibroScan可以替代肝活檢。對於確定ALT水平小於2 ULN的HBV感染患者是否應接受抗病毒治療具有重要意義。

關鍵字：ALT <2 ULN；纖維掃描儀;乙肝病毒感染；抗病毒治療的機會。

©2020 Xian-Zhi Han等，由De Gruyter發行。

StephenW

https://pubmed.ncbi.nlm.nih.gov/33817230/