乙型肝炎病毒感染与肝细胞脂质代谢之间的多方面相互作用

StephenW

Multifaceted Interaction Between Hepatitis B Virus Infection and Lipid Metabolism in Hepatocytes: A Potential Target of Antiviral Therapy for Chronic Hepatitis B
Jiaxuan Zhang  1 , Ning Ling  1 , Yu Lei  1 , Mingli Peng  1 , Peng Hu  1 , Min Chen  1
Affiliations
Affiliation

    1
    Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Department of Infectious Diseases, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

    PMID: 33776969 PMCID: PMC7991784 DOI: 10.3389/fmicb.2021.636897

Free PMC article
Abstract

Hepatitis B virus (HBV) is considered a "metabolic virus" and affects many hepatic metabolic pathways. However, how HBV affects lipid metabolism in hepatocytes remains uncertain yet. Accumulating clinical studies suggested that compared to non-HBV-infected controls, chronic HBV infection was associated with lower levels of serum total cholesterol and triglycerides and a lower prevalence of hepatic steatosis. In patients with chronic HBV infection, high ALT level, high body mass index, male gender, or old age was found to be positively correlated with hepatic steatosis. Furthermore, mechanisms of how HBV infection affected hepatic lipid metabolism had also been explored in a number of studies based on cell lines and mouse models. These results demonstrated that HBV replication or expression induced extensive and diverse changes in hepatic lipid metabolism, by not only activating expression of some critical lipogenesis and cholesterolgenesis-related proteins but also upregulating fatty acid oxidation and bile acid synthesis. Moreover, increasing studies found some potential targets to inhibit HBV replication or expression by decreasing or enhancing certain lipid metabolism-related proteins or metabolites. Therefore, in this article, we comprehensively reviewed these publications and revealed the connections between clinical observations and experimental findings to better understand the interaction between hepatic lipid metabolism and HBV infection. However, the available data are far from conclusive, and there is still a long way to go before clarifying the complex interaction between HBV infection and hepatic lipid metabolism.

Keywords: apolipoprotein; chronic hepatitis B; hepatic steatosis; hepatitis B virus; lipid metabolism; metabolic signaling pathway; nuclear factors.

Copyright © 2021 Zhang, Ling, Lei, Peng, Hu and Chen.

StephenW

乙型肝炎病毒感染与肝细胞脂质代谢之间的多方面相互作用：慢性乙型肝炎抗病毒治疗的潜在目标
张家璇1，宁玲1，于雷1，彭明利1，彭澎1，陈敏1
隶属关系
联系

    1个
    重庆医科大学附属第二医院病毒性肝炎研究所，传染病教研室，传染病分子生物学教育部重点实验室，重庆。

    PMID：33776969 PMCID：PMC7991784 DOI：10.3389 / fmicb.2021.636897

免费PMC文章
抽象的

乙型肝炎病毒（HBV）被认为是“代谢性病毒”，会影响许多肝脏的代谢途径。然而，HBV如何影响肝细胞脂质代谢尚不清楚。越来越多的临床研究表明，与未感染HBV的对照组相比，慢性HBV感染与血清总胆固醇和甘油三酸酯水平较低以及肝脂肪变性患病率较低相关。在患有慢性HBV感染的患者中，高ALT水平，高体重指数，男性或老年与肝脂肪变性呈正相关。此外，在许多基于细胞系和小鼠模型的研究中，还探讨了HBV感染如何影响肝脂质代谢的机制。这些结果表明，HBV复制或表达不仅通过激活一些关键的脂肪生成和胆固醇生成相关蛋白的表达，而且还通过上调脂肪酸氧化和胆汁酸的合成，从而引起肝脏脂质代谢的广泛而多样的变化。此外，越来越多的研究发现通过减少或增强某些脂质代谢相关蛋白或代谢物来抑制HBV复制或表达的一些潜在靶标。因此，在本文中，我们全面回顾了这些出版物，并揭示了临床观察结果与实验结果之间的联系，以更好地了解肝脂质代谢与HBV感染之间的相互作用。但是，现有数据远非结论性的，要弄清HBV感染与肝脂质代谢之间的复杂相互作用，还有很长的路要走。

关键词：载脂蛋白；慢性乙型肝炎肝脂肪变性乙型肝炎病毒;脂质代谢代谢信号通路核因素。

版权所有©2021张凌，雷，彭，胡和陈。

StephenW

https://pubmed.ncbi.nlm.nih.gov/33776969/