RIG-I样受体多态性影响中国汉族人群HBV清除率

StephenW

Polymorphisms of RIG-I-like receptor influence HBV clearance in Chinese Han Population
Yinan Yao  1 , Yan Shen  1 , Haifeng Shao  1 , Yuchang Liu  1 , Yan Ji  1 , Guoming Du  1 , Xiangyu Ye  2 , Peng Huang  2   3 , Haiming Chen  1
Affiliations
Affiliations

    1
    Department of Infectious Disease Control, Zhangjiagang Center for Disease Control and Prevention, No.18, Zhizhong Road, Zhangjiagang, Suzhou, 215600, China.
    2
    Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, No. 818 Tianyuan East Road, Jiangning District, Nanjing, 211166, China.
    3
    Key Laboratory of Infectious Diseases, School of Public Health, Nanjing Medical University, No. 818 Tianyuan East Road, Jiangning District, Nanjing, 211166, China.

    PMID: 33783003 DOI: 10.1002/jmv.26969

Abstract

Aims: Retinoic acid-inducible gene I-like receptors (RLRs) play an essential role in human innate immune, which may influence the spontaneous clearance of hepatitis B virus (HBV) infection. We aimed to investigate whether the SNPs in RLR family were associated with HBV spontaneous clearance.

Methods: The current study included 82 participants with spontaneous clearance, 601 asymptomatic hepatitis B surface antigen (HBsAg) carriers and 168 participants with chronic hepatitis B (CHB). Six SNPs (DDX58 rs3824456, rs3205166, DHX58 rs2074160, rs2074158, IFIH1 rs2111485, rs3747517) were genotyped to explore their association with HBV spontaneous clearance.

Results: Patients carrying the mutant allele C at rs3824456 or A at rs2074160 were more likely to achieve spontaneous clearance compared with asymptomatic HBsAg carriers (additive model: OR = 0.69, 95% CI = 0.49-0.97; dominant model: OR = 0.54, 95% CI = 0.31-0.95, respectively). In addition, patients carrying the mutant allele G at rs2111485 were more likely to achieve spontaneous clearance compared with CHB (dominant model: OR = 0.47, 95% CI = 0.25-0.87). The mutations were protective factors for HBV spontaneous clearance.

Conclusion: These results suggest the DDX58 rs3824456, DHX58 s2074160, IFIH1 rs2111485 were associated with spontaneous clearance of HBV, which may be predictive markers in the Chinese Han population of HBV. This article is protected by copyright. All rights reserved.

Keywords: HBV clearance; Hepatitis B virus; RLRs; polymorphism.

This article is protected by copyright. All rights reserved.

StephenW

RIG-I样受体多态性影响中国汉族人群HBV清除率
姚以南1，申延1，邵海峰1，刘玉昌1，严吉1，杜国明1，叶向宇2，黄鹏2 3，陈海明1
隶属关系
隶属关系

    1个
    张家港市疾病预防控制中心传染病控制司，江苏张家港市致中路18号，江苏苏州215600。
    2个
    南京医科大学公共卫生学院全球卫生中心流行病学教研室，南京市江宁区天元东路818号，南京211166
    3
    南京医科大学公共卫生学院传染病重点实验室，南京市江宁区天元东路818号，南京211166

    PMID：33783003 DOI：10.1002 / jmv.26969

抽象的

目的：维甲酸诱导的基因I样受体（RLR）在人类先天免疫中起重要作用，这可能会影响乙型肝炎病毒（HBV）感染的自发清除。我们旨在调查RLR家族中的SNP是否与HBV自发清除有关。

方法：本研究包括82名自发清除参与者，601名无症状乙型肝炎表面抗原（HBsAg）携带者和168名慢性乙型肝炎（CHB）参与者。对六个SNP（DDX58 rs3824456，rs3205166，DHX58 rs2074160，rs2074158，IFIH1 rs2111485，rs3747517）进行基因分型，以探讨它们与HBV自发清除的关联。

结果：与无症状HBsAg携带者相比，在rs3824456携带突变等位基因C或在rs2074160携带A的患者更有可能实现自发清除（加成模型：OR = 0.69，95％CI = 0.49-0.97；优势模型：OR = 0.54，95 ％CI分别为0.31-0.95）。此外，与CHB相比，在rs2111485上携带突变等位基因G的患者更有可能实现自发清除（优势模型：OR = 0.47，95％CI = 0.25-0.87）。突变是HBV自发清除的保护因素。

结论：这些结果表明DDX58 rs3824456，DHX58 s2074160，IFIH1 rs2111485与HBV的自发清除有关，这可能是中国汉族HBV人群的预测指标。本文受版权保护。版权所有。

关键词：HBV清除率；乙型肝炎病毒; RLR；多态性。

本文受版权保护。版权所有。