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Hydrogen treatment: a novel option in liver diseases
Jian Shi 1 , Brittany Duncan 2 , Xuyuan Kuang 3
Affiliations
Affiliations
1
The Third Xiangya Hospital, Changsha, China.
2
Weill Medical College, New York, USA.
3
Xiangya Hospital, Changsha, China [email protected].
PMID: 33762390 DOI: 10.7861/clinmed.2020-0370
Abstract
Hydrogen therapy is a very promising treatment against several diseases due to its mild attributes, high affinity and inherent biosafety. However, there is little elaboration about current hydrogen treatment in liver diseases. This article introduces the administration of hydrogen and mechanisms of hydrogen therapy in vivo, including modulating reactive oxygen species, apoptosis and autophagy, and inflammation, affecting mitochondria, as well as protein transporters. The major focus is clinical hydrogen use and related mechanisms in liver dysfunction or diseases, including non-alcoholic fatty liver disease, hepatitis B, liver dysfunction caused by liver tumour and colorectal tumour chemotherapy. Further, the article reveals ex vivo hydrogen application in liver protection. Finally, the article discusses the current and future challenges of hydrogen therapy in liver diseases, aiming to improve knowledge of hydrogen therapy and provide some insights into this burgeoning field.
Keywords: antioxidant and anti-inflammatory effect; evidence-based medicine; hydrogen therapy; liver diseases.
© Royal College of Physicians 2021. All rights reserved. |
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发表于 2021-3-26 20:57