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肝胆相照论坛 论坛 学术讨论& HBV English 氢治疗:肝脏疾病的新选择
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氢治疗:肝脏疾病的新选择 [复制链接]

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发表于 2021-3-26 20:57 |只看该作者 |倒序浏览 |打印
Hydrogen treatment: a novel option in liver diseases
Jian Shi  1 , Brittany Duncan  2 , Xuyuan Kuang  3
Affiliations
Affiliations

    1
    The Third Xiangya Hospital, Changsha, China.
    2
    Weill Medical College, New York, USA.
    3
    Xiangya Hospital, Changsha, China [email protected].

    PMID: 33762390 DOI: 10.7861/clinmed.2020-0370

Abstract

Hydrogen therapy is a very promising treatment against several diseases due to its mild attributes, high affinity and inherent biosafety. However, there is little elaboration about current hydrogen treatment in liver diseases. This article introduces the administration of hydrogen and mechanisms of hydrogen therapy in vivo, including modulating reactive oxygen species, apoptosis and autophagy, and inflammation, affecting mitochondria, as well as protein transporters. The major focus is clinical hydrogen use and related mechanisms in liver dysfunction or diseases, including non-alcoholic fatty liver disease, hepatitis B, liver dysfunction caused by liver tumour and colorectal tumour chemotherapy. Further, the article reveals ex vivo hydrogen application in liver protection. Finally, the article discusses the current and future challenges of hydrogen therapy in liver diseases, aiming to improve knowledge of hydrogen therapy and provide some insights into this burgeoning field.

Keywords: antioxidant and anti-inflammatory effect; evidence-based medicine; hydrogen therapy; liver diseases.

© Royal College of Physicians 2021. All rights reserved.

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发表于 2021-3-26 20:57 |只看该作者
氢治疗:肝脏疾病的新选择
剑石1,布列塔尼邓肯2,徐yuan匡3
隶属关系
隶属关系

    1个
    中国长沙湘雅三医院。
    2个
    美国纽约威尔医学院。
    3
    中国长沙湘雅医院[email protected]

    PMID:33762390 DOI:10.7861 / clinmed.2020-0370

抽象的

氢疗法因其温和的特性,高亲和力和固有的生物安全性,是一种针对多种疾病的非常有前途的疗法。但是,目前关于肝脏疾病中氢治疗的详细说明很少。本文介绍了体内氢的施用和氢治疗的机制,包括调节活性氧,凋亡和自噬以及炎症,影响线粒体以及蛋白质转运蛋白。临床重点是肝脏功能障碍或疾病中的临床氢气使用及相关机制,包括非酒精性脂肪肝,乙型肝炎,由肝肿瘤引起的肝功能障碍和结直肠肿瘤化疗。此外,该文章揭示了离体氢气在肝脏保护中的应用。最后,本文讨论了氢疗法在肝脏疾病中的当前和未来挑战,旨在提高对氢疗法的认识,并为这一新兴领域提供一些见识。

关键词:抗氧化和抗炎作用;循证医学;氢疗法;肝脏疾病。

©皇家内科医师学院2021。保留所有权利。

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2022-12-28 

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发表于 2021-3-26 20:57 |只看该作者
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