香港一般人群甲型和乙型肝炎的血清流行病学：在高度城市

StephenW

Seroepidemiology of hepatitis A and B in the general population in Hong Kong: protocol of a cross-sectional survey using spatial sampling in a highly urbanised city
March 23, 2021

This article was originally published here

BMJ Open. 2021 Mar 22;11(3):e042065. doi: 10.1136/bmjopen-2020-042065.

ABSTRACT

INTRODUCTION: Differences in immunisation policies have significantly reshaped the epidemiology of hepatitis A and B in the population. Assessment of the susceptibility and transmission potential of these two types of vaccine-preventable hepatitis would enhance the capacity of public health authorities for viral hepatitis elimination. Focusing on Hong Kong, the objectives of this study comprise the determination of the population-level seroprevalence of hepatitis A and B and an examination of the risk factors for virus transmission and the population impacts of vaccinations.

METHODS AND ANALYSIS: This is a cross-sectional household survey on hepatitis A and B. By using socially homogeneous building groups as sampling frame, eligible members of 1327 spatially selected households would be invited to complete a questionnaire and provide blood samples for serological testing (anti-hepatitis A virus, hepatitis B surface antigen, hepatitis B surface and core antibody). The main measures comprise a set of metrics on the prevalence of hepatitis A and B. Analysis would be conducted to examine the association of risk factors with the tested markers and describe the attitudes towards viral hepatitis vaccination.

ETHICS AND DISSEMINATION: Ethical approval from the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee, and approval for laboratory safety from the Chinese University of Hong Kong have been obtained. The study results will be presented in scientific forums to update on the epidemiology of hepatitis A and B and inform the development of new vaccination strategies in Hong Kong.

TRIAL REGISTRATION NUMBER: NCT04371276.

PMID:33753433 | DOI:10.1136/bmjopen-2020-042065

StephenW

香港一般人群甲型和乙型肝炎的血清流行病学：在高度城市化的城市中使用空间采样进行横断面调查的方案
2021年3月23日

本文最初发表在这里

BMJ公开赛。 2021年3月22日； 11（3）：e042065。 doi：10.1136 / bmjopen-2020-042065。

抽象的

简介：免疫政策的差异极大地改变了人群中甲型和乙型肝炎的流行病学。对这两类可预防疫苗的肝炎的易感性和传播潜力进行评估，将增强公共卫生当局消除病毒性肝炎的能力。以香港为重点，这项研究的目标包括确定甲型和乙型肝炎在人群中的血清阳性率，以及检查病毒传播的危险因素和接种疫苗对人群的影响。

方法和分析：这是一项关于甲型和乙型肝炎的横断面家庭调查。通过使用社会同质建筑群作为抽样框架，将邀请1327个在空间上选择的家庭的合格成员填写问卷并提供血液样本进行血清学检测（抗甲型肝炎病毒，乙型肝炎表面抗原，乙型肝炎表面和核心抗体）。主要措施包括一套有关甲型和乙型肝炎患病率的指标。将进行分析以检查危险因素与测试指标的关联，并描述对病毒性肝炎疫苗接种的态度。

道德与传播：已获得香港中文大学-新界东群集临床研究伦理委员会的道德批准，以及香港中文大学的实验室安全性批准。研究结果将在科学论坛上发布，以更新甲型和乙型肝炎的流行病学，并为香港新的疫苗接种策略的发展提供信息。

试用注册号：NCT04371276。

PMID：33753433 | DOI：10.1136 / bmjopen-2020-042065