新生儿乙肝疫苗接种可保护成年人免受隐性病毒感染

StephenW

Neonatal hepatitis B vaccination protects mature adults from occult virus infection
Ruijun Wang #  1 , Chang Liu #  1 , Taoyang Chen #  2 , Yuting Wang  1 , Chunsun Fan  2 , Lingling Lu  2 , Fengmin Lu  3 , Chunfeng Qu  4
Affiliations
Affiliations

    1
    State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan South Lane, Beijing, 100021, People's Republic of China.
    2
    Jiangsu, Qidong Liver Cancer Institute & Qidong People's Hospital, Qidong, 226200, People's Republic of China.
    3
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, People's Republic of China.
    4
    State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan South Lane, Beijing, 100021, People's Republic of China. [email protected].

#
Contributed equally.

    PMID: 33751394 DOI: 10.1007/s12072-021-10156-z

Abstract

Background: Among elder children/young adults who received hepatitis B virus (HBV) vaccination during infancy, the serological status of HBsAg-negative and anti-HBc-positive [HBsAg(-)/anti-HBc(+)] was frequently reported, indicating potential occult HBV infection (OBI). It is required to define the long-term protection of neonatal vaccination against OBI in their mature adulthood.

Methods: Building upon the 1983-1990 established Qidong Hepatitis B Intervention Study, we sampled 10% of the 28-35-year-old participants, who remained in the cohort by 2012. Each participant was tested for serological markers of HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc. HBV-DNA and relaxed circular DNA (rcDNA) were determined in some HBsAg(-)/anti-HBc(+) individuals.

Results: Totally, 3615 individuals from the neonatal vaccination group and 3100 individuals from the control group donated blood samples, respectively. In the vaccination group, the prevalence of HBsAg was 1.58% (57/3615), HBsAg(-)/anti-HBc(+) was 4.70% (170/3615), significantly lower than in the control group, which was 7.45% (231/3100) and 19.48% (640/3100) respectively (all p < 0.001). With aging, HBsAg(-)/anti-HBc(+) prevalence increased in the sampled participants from the control group (pfor trend < 0.001), but uncertain from the vaccination group. Of HBsAg(-)/anti-HBc(+), HBV-DNA was detected in 13.08% (17/130) from the vaccination group, and in 4.18% (12/287) from the control group. HBV rcDNA was detected in most sera that were tested positive for HBV-DNA.

Conclusions: OBI occurred in some vaccinated adults. However, neonatal HBV vaccination kept the effective protection against OBI in mature adults.

Keywords: Antibody against HBV core antigen; Antibody to hepatitis B surface antigen; HBV relaxed circular DNA; Hepatitis B vaccination; Hepatitis B virus; Long-term protection; Mature adults; Neonatal vaccination; Occult HBV infection; Serological survey.

StephenW

新生儿乙肝疫苗接种可保护成年人免受隐性病毒感染
王瑞军＃1，长柳＃1，陈涛阳＃2，王玉婷1，春笋范2，Ling陵路2，丰民路3，Chun春峰4
隶属关系
隶属关系

    1个
    中国医学科学院北京协和医科大学国家癌症中心/国家肿瘤研究中心/国家肿瘤医院分子肿瘤学国家重点实验室，北京潘家园南巷17号，中国北京100021。
    2个
    江苏省启东市肝癌研究所和启东市人民医院，江苏启东，226200。
    3
    北京大学健康科学中心基础医学学院微生物与传染病中心，天然与仿生药物国家重点实验室，北京100191
    4
    中国医学科学院北京协和医科大学国家癌症中心/国家肿瘤研究中心/国家肿瘤医院分子肿瘤学国家重点实验室，北京潘家园南巷17号，中国北京100021。 [email protected]。

＃
贡献均等。

    PMID：33751394 DOI：10.1007 / s12072-021-10156-z

抽象的

背景：在婴儿期接受乙型肝炎病毒（HBV）疫苗接种的年龄较大的儿童/年轻人中，经常报告HBsAg阴性和抗HBc阳性[HBsAg（-）/ anti-HBc（+）]的血清状况，表明潜在的隐匿性HBV感染（OBI）。需要定义成年成年后针对OBI的新生儿疫苗的长期保护。

方法：在1983-1990年建立的启东乙型肝炎干预研究的基础上，我们对28-35岁的参与者中的10％进行了抽样，这些参与者到2012年仍在该队列中。 HBs，HBeAg，抗HBe和抗HBc。在某些HBsAg（-）/ anti-HBc（+）个体中测定了HBV-DNA和松弛环状DNA（rcDNA）。

结果：新生儿疫苗接种组共有3615个人，对照组则有3100个人捐赠了血液样本。疫苗接种组中HBsAg的患病率为1.58％（57/3615），HBsAg（-）/抗HBc（+）的患病率为4.70％（170/3615），明显低于对照组的7.45％ （231/3100）和19.48％（640/3100）（所有p <0.001）。随着年龄的增长，对照组的样本参与者中的HBsAg（-）/抗-HBc（+）患病率增加（趋势<0.001的p值），但接种疫苗组对此不确定。在HBsAg（-）/抗HBc（+）中，从疫苗接种组中检出HBV-DNA的比例为13.08％（17/130），从对照组中检出HBV-DNA的率为4.18％（12/287）。在大多数血清中检测到HBV rcDNA，这些血清经检测均为HBV-DNA阳性。

结论：OBI发生在一些接种疫苗的成年人中。但是，新生儿HBV疫苗接种仍能有效保护成年人的OBI。

关键词：HBV核心抗原抗体；乙型肝炎表面抗原抗体； HBV松弛环状DNA；乙肝疫苗接种；乙型肝炎病毒;长期保护；成熟的成年人；新生儿疫苗接种；隐匿性HBV感染；血清学调查。