肝硬化中镁缺乏症的回顾性研究

StephenW

Magnesium deficiency in liver cirrhosis: a retrospective study
Xia Peng, Rengyun Xiang, Xuefeng Li, Hui Tian, Cuiqin Li, Zhi Peng & show all
Pages 463-468 | Received 05 Jan 2021, Accepted 31 Jan 2021, Published online: 01 Mar 2021

    Download citation https://doi.org/10.1080/00365521.2021.1888154 CrossMark Logo CrossMark


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Abstract
Background

Magnesium, known as “the forgotten electrolyte”, is an essential element of life. Magnesium deficiency is implicated in many diseases, including liver cirrhosis. This study aimed to explore the prevalence of magnesium deficiency in liver cirrhosis and investigate the relationship between magnesium levels and complication of liver cirrhosis and clinical outcomes.
Patients and methods

Cirrhotic patients with serum magnesium levels measured were retrospectively identified from 2016 to 2017. Demographics, laboratory parameters, complications were collected. The Child-Pugh class, MELD score, and ALBI score were calculated.
Results

The mean serum magnesium level of all 152 patients was lower than the normal, including 92 patients diagnosed with magnesium deficiency. Compared to Child-Pugh class A, magnesium levels were significantly lower in the patients with Child-Pugh class B or C (F = 10.26, p < .05). Magnesium levels were also considerably lower in the group with MELD score ≥21, compared to the other two groups with MELD score < 15 or 15–20 (F = 6.59, p < .05). Similarly, magnesium levels were significantly lower in the group with ALBI score > −1.39 (grade 3), compared to the other two groups with ALBI with score ≤ −2.6 (grade 1) or > −2.6, ≤ −1.39 (grade 2) (F = 8.44, p<.001). Furthermore, magnesium levels were lower in cirrhotic patients with infection. Magnesium-deficient patients had lower transplant-free survival rates than non-deficient patients.
Conclusion

Magnesium deficiency is highly prevalent in cirrhotic patients. Magnesium deficiency is related to worse transplant-free survival, infection and the severity of liver cirrhosis.

Keywords: Magnesium deficiency liver cirrhosis malnutrition Child-Pugh class MELD score ALBI score

StephenW

肝硬化中镁缺乏症的回顾性研究
夏鹏，向人运云，李雪峰，田慧，李翠琴，智鹏＆全部显示
第463-468页2021年1月5日收到，2021年1月31日接受，在线发布：2021年3月1日

    下载引文https://doi.org/10.1080/00365521.2021.1888154 CrossMark徽标CrossMark


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抽象的
背景

镁被称为“被遗忘的电解质”，是生命必不可少的元素。镁缺乏症涉及许多疾病，包括肝硬化。本研究旨在探讨肝硬化中镁缺乏症的患病率，并探讨镁水平和肝硬化并发症与临床结局之间的关系。
患者和方法

从2016年至2017年，对肝硬化患者的血清镁水平进行了回顾性鉴定。计算Child-Pugh等级，MELD分数​​和ALBI分数。
结果

所有152例患者的平均血清镁水平均低于正常水平，其中包括92例被诊断为镁缺乏症的患者。与Child-Pugh A级相比，Child-Pugh B级或C级患者的镁水平显着降低（F = 10.26，p <0.05）。与其他两个MELD评分<15或15-20的组相比，MELD评分≥21的组中的镁含量也显着降低（F = 6.59，p <.05）。同样，ALBI得分> -1.39（3级）组的镁水平明显低于ALBI得分≤-2.6（1级）或> -2.6，≤-1.39（2级）的其他两组。 （F ＝ 8.44，p ＜.001）。此外，肝硬化感染患者的镁水平较低。缺镁患者的无移植生存率低于无缺镁患者。
结论

镁缺乏症在肝硬化患者中非常普遍。镁缺乏症与无移植物生存，感染和肝硬化严重程度有关。

关键词：镁缺乏肝硬化营养不良Child-Pugh级MELD评分ALBI评分