核苷酸（t）核苷酸类似物治疗整个妊娠期间慢性乙型肝炎的

StephenW

Analysis of long-term safety and efficacy of nucleos(t)ide analogue therapy for chronic hepatitis B during entire pregnancy
Jin Shang  1 , Huan Liu  1 , Qin Wen  1 , Rili M Ise  1 , You Tu  1 , Lang Bai  2 , Hong Tang  3
Affiliations
Affiliations

    1
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    2
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: [email protected].
    3
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: [email protected].

    PMID: 33722684 DOI: 10.1016/j.ijid.2021.03.023

Abstract

Objectives: There are limited data on the efficacy and long-term safety of nucleos(t)ide analogue therapy during the entire pregnancy for chronic hepatitis B women and their children.

Methods: This retrospective cohort study included totally 165 patients including 91 patients in telbivudine (LDT) group and 74 patients in tenofovir (TDF) group. The virological response and safety in women were recorded and the physical development and bone mineral density in children was followed up to five years old.

Results: The rate of virological breakthrough was 4.24% in all patients, 7.70% in LDT group and 0% in TDF group (P < 0.05). No renal injury or other obstetric adverse event in women was found. As for the physical development or bone density of children, only one child has significant low wight of age Z score (<-2) and no significant low height for age Z score or bone density was found in children, there was no significant difference between the two groups.

Conclusions: Nucleos(t)ide analogue therapy including TDF and LDT during entire pregnancy showed no effect on long-term physical development and bone development of children. Additional, TDF during their entire pregnancy showed better long-term antiviral efficacy than LDT with no evidence of renal toxicity.

Keywords: Hepatitis B virus; Nucleos(t)ide analogue; Pregnancy; Telbivudine; Tenofovir.

Copyright © 2021. Published by Elsevier Ltd.

StephenW

核苷酸（t）核苷酸类似物治疗整个妊娠期间慢性乙型肝炎的长期安全性和疗效分析
金尚1，幻柳1，秦文1，黎M 1 1，游图1，郎白2，红塘3
隶属关系
隶属关系

    1个
    四川大学华西医院传染病中心，四川成都
    2个
    四川大学华西医院传染病中心，四川成都电子地址：[email protected]。
    3
    四川大学华西医院传染病中心，四川成都电子地址：[email protected]。

    PMID：33722684 DOI：10.1016 / j.ijid.2021.03.023

抽象的

目的：关于慢性乙型肝炎妇女及其子女整个妊娠期间核苷类似物疗法的疗效和长期安全性的数据有限。

方法：这项回顾性队列研究共纳入165例患者，其中替比夫定（LDT）组为91例，替诺福韦（TDF）组为74例。记录了妇女的病毒学应答和安全性，并跟踪了五岁以下儿童的身体发育和骨矿物质密度。

结果：所有患者的病毒学突破率分别为4.24％，LDT组为7.70％，TDF组为0％（P <0.05）。未发现女性有肾损伤或其他产科不良事件。至于儿童的身体发育或骨密度，只有一个儿童的Z年龄权重显着低（<-2），而Z年龄的高矮度或骨密度没有显着低，儿童之间没有显着差异。两组。

结论：整个妊娠期间包括TDF和LDT在内的核苷类似物治疗对儿童的长期身体发育和骨骼发育没有影响。另外，TDF在整个妊娠期显示出比LDT更好的长期抗病毒功效，没有肾毒性的证据。

关键字：乙型肝炎病毒；核苷类似物;怀孕;替比夫定;替诺福韦。

版权所有©2021.由Elsevier Ltd.发布。