活动性慢性乙型肝炎病毒感染和非活动性携带者影响患者血

StephenW

Trend of 25-hydroxycholesterol and 27-hydroxycholesterol plasma levels in patients affected by active chronic hepatitis B virus infection and inactive carriers
Lucio Boglione  1 , Claudio Caccia  2 , Andrea Civra  3 , Jessica Cusato  4 , Antonio D'Avolio  4 , Fiorella Biasi  3 , David Lembo  3 , Giovanni Di Perri  4 , Giuseppe Poli  5 , Valerio Leoni  6
Affiliations
Affiliations

    1
    Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
    2
    Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
    3
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.
    4
    Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
    5
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy. Electronic address: [email protected].
    6
    Laboratory of Clinical Chemistry, Hospital of Desio, ASST-Monza and Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. Electronic address: [email protected].

    PMID: 33631373 DOI: 10.1016/j.jsbmb.2021.105854

Abstract

Hepatitis B virus (HBV) infection is a global health problem with different immunological phases and therapeutic approaches. The serological condition of inactive carrier (IC) was recently well defined as a clinical and virological stable status, in which specific treatment is usually deferred, while the active chronic hepatitis B (CHB) condition requires an immediate treatment strategy. Recently, a possible broad antiviral effect of oxysterols, in particular 25-hydroxycholesterol (25OHC) and 27-hydroxycholesterol (27OHC), was observed, as most likely linked to the positive modulation of innate immunity, but no clear evidence is available about their possible role in chronic HBV infection. Thus, we examined the relationship between the plasma levels of oxysterols and the disease condition of 40 HBV patients, without treatment at the start of the study. Of these, 33 were ICs and 7 were active CHB subjects. A marked reduction of 25OHC and 27OHC plasma levels was detectable in all active CHB recruited patients, while the plasma values observed in ICs all remained within the physiological range. No difference was observed between the two groups of patients with regard to the plasma levels of 24-hydroxycholesterol (24OHC). Further, the plasma level of 27OHC ≥ 140 μg/L was shown to be predictive of an inactive carrier status. This cohort study points to 27OHC as a good candidate biomarker to differentiate active and inactive CHB status. An increasing bulk of research reports is supporting the very likely contribution of this oxysterol to the immunological control of chronic hepatitis B.

Keywords: 27-hydroxycholesterol; active CHB; hepatitis B virus; inactive carriers; oxysterols.

Copyright © 2021. Published by Elsevier Ltd.

StephenW

活动性慢性乙型肝炎病毒感染和非活动性携带者影响患者血浆25-羟胆固醇和27-羟胆固醇的趋势
Lucio Boglione 1，Claudio Caccia 2，Andrea Civra 3，Jessica Cusato 4，Antonio D'Avolio 4，Fiorella Biasi 3，David Lembo 3，Giovanni Di Perri 4，Giuseppe Poli 5，Valerio Leoni 6
隶属关系
隶属关系

    1个
    东皮埃蒙特大学，意大利诺瓦拉，转化医学系。
    2
    意大利米兰基金会IRCCS Istituto Neuroologico Carlo Besta医学遗传学和神经遗传学部门。
    3
    都灵大学临床和生物科学系，意大利都灵Orbassano的San Luigi医院。
    4
    都灵大学医学系传染病科，意大利都灵Amedeo di Savoia医院。
    5
    都灵大学临床和生物科学系，意大利都灵Orbassano的San Luigi医院。电子地址：[email protected]。
    6
    意大利米兰-比可卡大学，德蒙大学附属科学研究院，蒙大拿州科学技术大学临床化学实验室，医学和外科系。电子地址：[email protected]。

    PMID：33631373 DOI：10.1016 / j.jsbmb.2021.105854

抽象的

乙肝病毒（HBV）感染是全球性的健康问题，具有不同的免疫学阶段和治疗方法。无效载体（IC）的血清学状况最近被明确定义为临床和病毒学稳定状态，其中通常推迟进行特异性治疗，而活动性慢性乙型肝炎（CHB）状况则需要立即采取治疗策略。最近，观察到氧固醇，尤其是25-羟基胆固醇（25OHC）和27-羟基胆固醇（27OHC）可能具有广泛的抗病毒作用，因为它很可能与先天免疫的正调节有关，但尚无明确的证据表明它们可能起作用。在慢性HBV感染中的作用。因此，我们在研究开始时就检查了氧固醇的血浆水平与40例HBV患者疾病状况之间的关系。在这些人中，有33位是IC，有7位是活跃的CHB受试者。在所有活跃的CHB征募患者中，血浆25OHC和27OHC的水平均显着降低，而在IC中观察到的血浆值均保持在生理范围内。两组患者的血浆24-羟基胆固醇（24OHC）水平没有差异。此外，血浆27OHC≥140μg/ L被证明可预测载体处于非活动状态。这项队列研究表明27OHC是区分活跃和非活跃CHB状态的良好候选生物标志物。越来越多的研究报告支持这种氧固醇很可能对慢性乙型肝炎的免疫控制做出贡献。

关键字：27-羟基胆固醇；活跃的CHB;乙型肝炎病毒;不活跃的运营商；氧固醇。

版权所有©2021.由Elsevier Ltd.发布。