治疗非酒精性脂肪性肝炎的草药

StephenW

Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis

    Naemat Sandhu & Jennifer Au

Current Hepatology Reports volume 20, pages1–11(2021)Cite this article

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Abstract
Purpose of Review

Nonalcoholic fatty liver disease encompasses both, nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH). The prevalence of NASH is rising globally and has become one of the leading causes of chronic liver disease and indications for liver transplantation. Its complex and multifaceted pathophysiology makes the management of NASH challenging. In the absence of effective pharmacotherapies, there has been an increasing interest for the use of herbal medicines/supplements in the treatment of NASH. Here we review some of the more popular herbal medicines/supplements used to treat NASH.
Recent Findings

In the last decade, there have been numerous herbal medicines which have been studied as treatments for NASH with promising results in animal studies and in vitro studies. The data however is conflicting in clinical trials and lacking with regard to long-term safety and hepatotoxicity.
Summary

Herbal medicines have continued to gain popularity as treatment options for NASH given their easy accessibility and paucity of FDA-approved pharmacotherapies. The data to support the use of these products for NASH remains inconclusive and at this time, there is no herbal medicine which should be recommended in the treatment of NASH.

StephenW

治疗非酒精性脂肪性肝炎的草药

    Naemat Sandhu和Jennifer Au

《当前肝病学报告》第20卷，第1-11（2021页）

    28次访问

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抽象的
审查目的

非酒精性脂肪肝疾病包括非酒精性脂肪肝和非酒精性脂肪性肝炎（NASH）。 NASH的流行在全球范围内正在上升，已成为慢性肝病的主要原因之一和肝移植的适应症。其复杂而多方面的病理生理学使NASH的管理具有挑战性。在缺乏有效的药物治疗的情况下，人们越来越关注在NASH的治疗中使用草药/补充剂。在这里，我们回顾一些用于治疗NASH的较流行的草药/补充剂。
最近的发现

在过去的十年中，已经有许多草药被研究作为NASH的治疗方法，在动物研究和体外研究中均取得了可喜的成果。但是，该数据在临床试验中存在矛盾，并且缺乏长期安全性和肝毒性。
概括

由于NASH易于获取且缺乏FDA批准的药物治疗方法，因此草药一直是NASH的治疗选择。支持将这些产品用于NASH的数据尚无定论，目前，尚无推荐用于NASH治疗的草药。