瘦肉代谢性脂肪肝疾病的代谢特征和身体组成

StephenW

The metabolic profiles and body composition of lean metabolic associated fatty liver disease

    February 2021Hepatology International

    DOI: 10.1007/s12072-021-10147-0

    Yu-Ming ChengJia-Horng KaoJia-Horng KaoChia-Chi Wang

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The metabolic profiles and body composition of lean metabolic associated fatty liver disease
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Abstract
Background/purpose
Metabolic associated fatty liver disease (MAFLD) is the commonest cause of chronic liver disease, which is associated with obesity and diabetes. However, it also occurs in lean individuals especially in Asian populations.
Methods
The participants of Tzu Chi MAFLD cohort (TCMC) including health controls or MAFLD patients were enrolled. MAFLD was defined as fatty liver in imaging without hepatitis B virus, hepatitis C virus infection, drug, alcohol or other known causes of chronic liver disease. Lean MAFLD was defined as MAFLD in lean subjects (BMI < 23 kg/m2). ResultsA total of 880 subjects were included for final analysis. Of 394 MAFLD patients, 65 (16.5%) patients were diagnosed as lean MAFLD. Lean MAFLD patients were elder, higher percentage of female gender, lower ALT, diastolic blood pressure, triglyceride, and waist circumference but higher HDL than non-lean MAFLD patients. Using binary regression analysis, elder age and lower waist circumference were associated with lean MAFLD. Compared with lean healthy controls, lean MAFLD patients had higher BMI, waist circumference, and percentage of hypertension. In body composition, fatty tissue index (FTI), lean tissue index (LTI) ,and total body water (TBW) were lower in lean MAFLD than non-lean MAFLD patients; but they were comparable with lean healthy controls.
Conclusions
The prevalence of lean MAFLD was 16.5% in this study population and it was higher in elder age, especially of female subjects. Lean MAFLD patients had different metabolic profiles compared with lean healthy controls, but different body composition compared with non-lean MAFLD patients.

StephenW

瘦肉代谢性脂肪肝疾病的代谢特征和身体组成

    2021年2月

    DOI：10.1007 / s12072-021-10147-0

    程玉明贾家宏高家宏王家琪

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瘦肉代谢性脂肪肝疾病的代谢特征和身体组成
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抽象
背景/目的
代谢相关性脂肪肝疾病（MAFLD）是慢性肝病的最常见原因，而慢性肝病与肥胖症和糖尿病有关。但是，它也发生在瘦弱的人中，尤其是在亚洲人口中。
方法
包括健康对照或MAFLD患者在内的Tzu Chi MAFLD队列（TCMC）的参与者入组。 MAFLD在影像学中被定义为脂肪肝，无乙型肝炎病毒，丙型肝炎病毒感染，药物，酒精或其他已知原因引起的慢性肝病。瘦MAFLD被定义为瘦受试者（BMI <23 kg / m2）中的MAFLD。结果共纳入880名受试者进行最终分析。在394名MAFLD患者中，有65名（16.5％）患者被诊断为瘦MAFLD。瘦的MAFLD患者年龄较大，女性百分比更高，ALT，舒张压，甘油三酸酯和腰围较低，但HDL高于非瘦MAFLD患者。使用二元回归分析，高龄和下腰围与瘦身肥胖相关。与瘦身健康对照组相比，瘦身MAFLD患者的BMI，腰围和高血压百分比更高。在身体组成方面，瘦MAFLD患者的脂肪组织指数（FTI），瘦组织指数（LTI）和全身水（TBW）低于非瘦MAFLD患者。但它们可与精益健康对照组媲美。
结论
瘦MAFLD的患病率在该研究人群中为16.5％，并且在老年人中更高，尤其是女性受试者。瘦的MAFLD患者与瘦的健康对照组相比具有不同的代谢谱，但与非瘦的MAFLD患者相比则具有不同的身体组成。