慢性乙型肝炎肝脂肪变性分级控制减毒参数分析

StephenW

Analysis of liver steatosis analysis and controlled attenuation parameter for grading liver steatosis in patients with chronic hepatitis B
Xinping Ren  1   2 , Shujun Xia  1 , Lu Zhang  1 , Ruokun Li  3 , Wei Zhou  1 , Ri Ji  1 , Jianqiao Zhou  1 , Jingyan Tian  4 , Weiwei Zhan  1
Affiliations
Affiliations

    1
    Department of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    2
    Department of Ultrasound, Wuxi Branch of Ruijin Hospital, Wuxi, China.
    3
    Institute of Endocrinology, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    4
    Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

    PMID: 33532257 PMCID: PMC7779909 DOI: 10.21037/qims-19-1091

Abstract

Background: Chronic hepatitis B is the most common chronic liver disease in China. For patients with chronic hepatitis B, steatosis increases the risk of cirrhosis and hepatocellular carcinoma. This study aimed to analyze and compare the clinical value of a newly developed ultrasound attenuation parameter, liver steatosis analysis (LiSA), acquired by Hepatus (Mindray, China), and controlled attenuation parameter (CAP), a widely used ultrasound attenuation parameter acquired by FibroScan (Echosens, France), for grading liver steatosis in patients with chronic hepatitis B infection.

Methods: A total of 203 patients were divided into two groups according to liver fat content validated by liver biopsy: group 1 (liver fat content <10%) and group 2 (liver fat content ≥10%). All patients underwent LiSA and CAP examinations. Receiver operating characteristic (ROC) curves were calculated for the two ultrasound attenuation tools.

Results: Both LiSA and CAP successfully discriminated between patients in group 1 and group 2. ROC curves showed that both tools had good diagnostic ability (AUC: >0.7) for steatosis ≥10%, and the performance of LiSA was significantly better than CAP (AUC: 0.859 vs. 0.801, P=0.048). Using optimal cut-off points, LiSA had specificity and sensitivity of 96.23% and 76.08%, respectively, for the diagnosis of steatosis ≥10%, compared to 91.53% and 72.10%, respectively, for CAP.

Conclusions: LiSA and CAP are extremely efficient tools for assessing liver steatosis, even at a low grade. Both parameters are non-invasive, inexpensive, and easy to use, and can provide immediate results with high sensitivity.

Keywords: Liver steatosis; chronic hepatitis B; controlled attenuation parameter (CAP); liver steatosis analysis (LiSA); ultrasound attenuation parameter.

2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.

StephenW

慢性乙型肝炎肝脂肪变性分级控制减毒参数分析
任新平1 2，夏树军1，陆章1，李若坤3，周1，日籍1，周建乔1，田景艳4，战维1
隶属关系
隶属关系

    1个
    上海交通大学医学院附属瑞金医院超声科，上海
    2
    中国无锡瑞金医院无锡分院超声科
    3
    上海交通大学医学院内分泌研究所，上海
    4
    上海交通大学医学院附属瑞金医院内分泌代谢研究所，内分泌代谢科，上海

    PMID：33532257 PMCID：PMC7779909 DOI：10.21037 / qims-19-1091

抽象

背景：慢性乙型肝炎是中国最常见的慢性肝病。对于患有慢性乙型肝炎的患者，脂肪变性会增加肝硬化和肝细胞癌的风险。这项研究的目的是分析和比较由Hepatus（Mindray，China）获得的最新开发的超声衰减参数，肝脂肪变性分析（LiSA）和通过控制获得的广泛使用的超声衰减参数（CAP）的临床价值。 FibroScan（法国Echosens），用于对慢性乙型肝炎患者进行肝脂肪变性分级。

方法：根据经肝活检证实的肝脂肪含量，将203例患者分为两组：第一组（肝脏脂肪含量<10％）和第二组（肝脏脂肪含量≥10％）。所有患者均接受LiSA和CAP检查。计算了两个超声衰减工具的接收器工作特性（ROC）曲线。

结果：LiSA和CAP均成功地区分了第1组和第2组患者。ROC曲线显示，这两种工具对脂肪变性≥10％均具有良好的诊断能力（AUC：> 0.7），并且LiSA的性能明显优于CAP（ AUC：0.859与0.801，P = 0.048）。使用最佳分界点，LiSA诊断脂肪变性≥10％的特异性和敏感性分别为96.23％和76.08％，而CAP分别为91.53％和72.10％。

结论：LiSA和CAP是评估肝脂肪变性的非常有效的工具，即使在低等级时也是如此。这两个参数都是非侵入性的，廉价的并且易于使用，并且可以以高灵敏度提供即时结果。

关键字：肝脂肪变性；慢性乙型肝炎控制衰减参数（CAP）；肝脂肪变性分析（LiSA）；超声衰减参数。

2021年医学和外科手术中的定量成像。版权所有。

StephenW

https://qims.amegroups.com/article/view/56711/html