实时剪切波弹性造影在区分肝细胞癌和其他肝局灶性病变中

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Role of real-time shear-wave elastogarphy in differentiating hepatocellular carcinoma from other hepatic focal lesions

Gad, Magdy A. Mawgooda; Eraky, Tamer E.a; Omar, Hazem M.b; Abosheaishaa, Hazem MaaroufaAuthor Information
European Journal of Gastroenterology & Hepatology: March 2021 - Volume 33 - Issue 3 - p 407-414
doi: 10.1097/MEG.0000000000001741

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Abstract
Background:

Hepatocellular carcinoma (HCC) has an increasing incidence worldwide, and is considered the second cause of cancer-related death.
Aim:

The aim of the study is to assess the usefulness of real-time shear-wave elastography in differentiating HCC from other hepatic focal lesions.
Patients and methods:

The current study was conducted on 110 patients in addition to 10 healthy subjects, divided into four groups as follows: liver cirrhosis, HCC, hepatic focal lesions other than HCC, and control. Demographic, laboratory and imaging data were collected and then elastographic assessment of the hepatic focal lesions and the surrounding liver parenchyma using elastograph point quantification (ElastPQ) (iU22x MATRIX, Philips) was done.
Results:

ElastPQ (iU22x MATRIX, Philips) has shown its ability to differentiate between HCC and cystic focal lesions, HCC and cholangiocarcinoma, and HCC and focal nodular hyperplasia (FNH). Cystic lesions demonstrated lower stiffness in comparison to HCC; however, cholangiocarcinoma and FNH demonstrated higher stiffness in comparison to HCC. ElastPQ was unable to differentiate between stiffness in both ‘HCC and hemangioma’ and ‘HCC and metastatic focal lesions’. ElastPQ showed that HCC, cystic focal lesions, and cholangiocarcinoma had lower stiffness in comparison to their surrounding liver parenchyma, whereas FNH had higher stiffness in comparison to the surrounding liver parenchyma. ElastPQ showed that the surrounding liver parenchyma of the HCC group has the highest stiffness amongst all studied hepatic focal lesions surrounding liver parenchyma.
Conclusion:

‘Point’ shear-waves elastography (ElastPQ; Philips iU22x MATRIX, Philips) is a noninvasive, quantitative and nonradiating method for evaluation of tissue elasticity, and is helpful in differentiating HCC from other hepatic focal lesions.
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

StephenW

实时剪切波弹性造影在区分肝细胞癌和其他肝局灶性病变中的作用

Gad，Magdy A. Mawgooda； Eraky，Tamer E.a；奥马尔（Omar），哈兹姆（Hazem M.b）； Abosheaishaa，Hazem Maaroufa作者信息
欧洲胃肠病学和肝病学杂志：2021年3月-第33卷-第3期-p 407-414
doi：10.1097 / MEG.0000000000001741

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抽象
背景：

肝细胞癌（HCC）在世界范围内的发病率不断上升，被认为是与癌症相关的死亡的第二大原因。
目标：

这项研究的目的是评估实时剪切波弹性成像在区分HCC和其他肝局灶性病变中的有用性。
患者和方法：

除10名健康受试者外，本研究还针对110位患者进行了研究，分为四组：肝硬化，HCC，除HCC以外的肝局灶性病变和对照组。收集人口统计学，实验室和成像数据，然后使用弹性成像点量化（ElastPQ）（iU22x MATRIX，Philips）对肝脏局灶性病变和周围的肝实质进行弹性成像评估。
结果：

ElastPQ（iU22x MATRIX，Philips）已显示出区分HCC和囊性局灶性病变，HCC和胆管癌以及HCC和局灶性结节性增生（FNH）的能力。与HCC相比，囊性病变表现出较低的硬度；然而，与HCC相比，胆管癌和FNH表现出更高的硬度。 ElastPQ无法区分“ HCC和血管瘤”和“ HCC和转移性局灶性病变”的僵硬程度。 ElastPQ显示，与周围肝实质相比，HCC，囊性局灶性病变和胆管癌具有较低的硬度，而与周围肝实质相比，FNH具有较高的硬度。 ElastPQ显示，在所有研究的肝实质周围肝局灶性病变中，HCC组的周围肝实质具有最高的硬度。
结论：

“点”剪切波弹性成像（ElastPQ； Philips iU22x MATRIX，Philips）是一种非侵入性，定量和非放射性的方法，用于评估组织弹性，有助于将HCC与其他肝局灶性病变区分开。
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