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回复 赣江白话 的帖子
"考虑到TAF血脂异常的副作用" - 通常这在少数艾滋病毒患者中观察到 . 用 TDF, 较低的LDL,较高的HDL . 用TAF, 空腹血脂浓度保持稳定.
https://www.google.com/url?sa=t& ... bR-DPRIU74GHHjHYZtA
As compared with other antiretroviral agents, TDF adminis-tration has been associated with lower fasting direct low-den-sity lipoprotein (LDL) cholesterol levels and higher fasting high-density lipoprotein (HDL) cholesterol, and this effect generally correlates with the tenofovir plasma levels [17]. Consistent with the lower plasma tenofovir concentration asso-ciated with TAF, fasting lipid concentrations remained relatively stable through week 48 in the TAF group, whereas TDF admin-istration resulted in the expected lipid-lowering effect, with decreases from baseline. Overall, the changes in the median total cholesterol, LDL cholesterol, HDL cholesterol, and tri-glyceride values in the TAF group were not clinically relevant.
与其他抗逆转录病毒药物相比,TDF的给药与较低的空腹直接低密度脂蛋白(LDL)胆固醇水平和较高的空腹高密度脂蛋白(HDL)胆固醇相关,这种作用通常与替诺福韦血浆相关 水平[17]。 与TAF相关的血浆替诺福韦浓度较低相一致,在TAF组至第48周时,空腹血脂浓度保持相对稳定,而TDF给药导致预期的血脂降低作用,与基线相比降低。 总体而言,TAF组中总胆固醇,LDL胆固醇,HDL胆固醇和甘油三酸酯值的变化与临床无关。 |
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