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FIB-5 versus FIB-4 index for assessment of hepatic fibrosis in chronic hepatitis B affected patients
Khaled Metwally 1 , Maha Elsabaawy 1 , Mohamed Abdel-Samiee 1 , Wessam Morad 2 , Nermine Ehsan 3 , Eman Abdelsameea 1
Affiliations
Affiliations
1
Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Egypt.
2
Community and Preventive Medicine Department, National Liver Institute, Menoufia University, Egypt.
3
Pathology Department, National Liver Institute, Menoufia University, Egypt.
PMID: 33511281 PMCID: PMC7816634 DOI: 10.5114/ceh.2020.102157
Free PMC article
Abstract
Aim of the study: Chronic hepatitis B virus (HBV) infection is one of the major health problems worldwide. Use of non-invasive tests for assessment of hepatic fibrosis such as the FIB-4 index could be used to avoid liver biopsy. Another promising noninvasive test, FIB-5, could also be used to detect significant hepatic fibrosis. The aim of the study was to compare the use of FIB-5 and FIB-4 as noninvasive markers to assess chronic HBV-related hepatic fibrosis.
Material and methods: This study was done on 176 chronic HBV patients who underwent liver biopsy. Grading and staging of liver fibrosis was done according to the METAVIR scoring system. FIB-5 and FIB-4 scores were calculated for all patients.
Results: As regards FIB-4 for differentiation between non-significant fibrosis (group I) and significant fibrosis (group II), at a cutoff level of 1.28 with positive predictive value (PPV) 41.4% and specificity 48% while at a cutoff level of 7.08 with PPV 98.8% and specificity 98% for FIB-5.
Conclusions: As regards both scores, the FIB-5 score was more specific than FIB-4 for diagnosing significant from nonsignificant hepatic fibrosis in patients with chronic HBV infection.
Keywords: FIB-4; FIB-5; biopsy; chronic HBV; fibrosis.
Copyright: © 2020 Clinical and Experimental Hepatology. |
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发表于 2021-2-1 20:31