二維剪切波彈性成像，磁共振彈性成像和三种血清標誌物在

StephenW

Comparison of two-dimensional shear wave elastography, magnetic resonance elastography, and three serum markers for diagnosing fibrosis in patients with chronic hepatitis B: a meta-analysis
Bingtian Dong , Guorong Lyu , Yuping Chen , Guofu Lin , Huaming Wang , Ran Qin & show all
Received 12 Dec 2020, Accepted 21 Jan 2021, Accepted author version posted online: 25 Jan 2021

    Download citation https://doi.org/10.1080/17474124.2021.1880894 CrossMark Logo CrossMark

Accepted author version
Abstract
Background

: Two-dimensional shear wave elastography (2D-SWE), magnetic resonance elastography (MRE), aspartate transaminase-to-platelet ratio index (APRI), fibrosis index based on 4 factors (FIB-4) and King’s score have been proposed for diagnosing liver fibrosis.
Methods

Literature databases were searched until October 1st, 2020. The summary area under the receiver operating characteristic curve (AUROC), the summary diagnostic odds ratios, and the summary sensitivities and specificities were used to assess the diagnostic performance of these non-invasive methods for staging fibrosis.
Results

: Our final data contained 72 studies. The overall mean prevalence of significant fibrosis, advanced fibrosis and cirrhosis was 58.3%, 36.2% and 20.5%, respectively, in chronic hepatitis B (CHB) patients. For imaging techniques (2D-SWE and MRE), the summary AUROCs were 0.89 and 0.97, 0.95 and 0.97, and 0.94 and 0.97 for significant fibrosis, advanced fibrosis, and cirrhosis, respectively. The summary AUROCs using APRI and FIB-4 for detecting significant fibrosis, advanced fibrosis and cirrhosis were 0.76 and 0.75, 0.74 and 0.77, 0.77 and 0.82, respectively. The summary AUROCs of King’s score for detecting significant fibrosis and cirrhosis were 0.77 and 0.83, respectively.
Conclusion

MRE and 2D-SWE may show the best diagnostic accuracy for predicting fibrosis in CHB. Among the three serum markers, King’s score may be more useful for diagnosing fibrosis.

Keywords: chronic hepatitis Bliver fibrosisimaging techniquesserum markersnon-invasive methods

StephenW

二維剪切波彈性成像，磁共振彈性成像和三种血清標誌物在慢性乙型肝炎患者纖維化診斷中的比較：薈萃分析
董炳田，呂國榮，陳玉萍，林國富，王華明，秦然＆全部顯示
2020年12月12日收到，2021年1月21日接受，在線發布的作者版本：2021年1月25日

    下載引文https://doi.org/10.1080/17474124.2021.1880894 CrossMark徽標CrossMark

接受的作者版本
抽象
背景

：提出了二維剪切波彈性成像（2D-SWE），磁共振彈性成像（MRE），天冬氨酸轉氨酶與血小板比率指數（APRI），基於4個因素的纖維化指數（FIB-4）和King評分診斷肝纖維化。
方法

檢索文獻數據庫直至2020年10月1日。使用接收器工作特徵曲線（AUROC）下的摘要區域，摘要診斷比值比以及摘要敏感性和特異性來評估這些無創分期方法的診斷性能纖維化。
結果

：我們的最終數據包含72項研究。在慢性乙型肝炎（CHB）患者中，顯著纖維化，晚期纖維化和肝硬化的總體平均患病率分別為58.3％，36.2％和20.5％。對於成像技術（2D-SWE和MRE），對於明顯的纖維化，晚期纖維化和肝硬化，總結的AUROC分別為0.89和0.97、0.95和0.97以及0.94和0.97。使用APRI和FIB-4進行顯著纖維化，晚期纖維化和肝硬化檢測的AUROC匯總分別為0.76和0.75、0.74和0.77、0.77和0.82。 King的發現嚴重纖維化和肝硬化的總AUROC分別為0.77和0.83。
結論

MRE和2D-SWE可能顯示出預測CHB纖維化的最佳診斷準確性。在這三种血清標誌物中，金氏評分可能更有助於診斷纖維化。

關鍵詞：慢性乙型肝炎肝纖維化成像技術血清標誌物-浸潤方法