FIB4和APRI评分预测慢性乙型肝炎病毒感染患者纤维化的表现

StephenW

Performance of FIB4 and APRI scores for the prediction of fibrosis in patients with chronic hepatitis B virus infection
Mouna Medhioub, Wafa Ben Salah, Amal Khsiba, Alaa Ouni, Lamine Hamzaoui, Mohamed Moussadek Azouz

    PMID: 33480003

Abstract

Background: The evaluation of hepatic fibrosis is essential in the therapeutic management of chronic hepatitis B virus infection. The development of non-invasive tests for liver fibrosis assessement has allowed to avoid liver biops in some cases.

Aim: To assess the performance of the scores APRI and FIB-4 in the assessment of significant fibrosis in chronic hepatitis B virus infection.

Methods: Evaluation study, including patients with chronic hepatitis B virus infection who had a liver biopsy. The accuracy of APRI and FIB4 for the detection of significant fibrosis was compared with the liver biopsy data.

Results: One hundred and one patients were included. Significant fibrosis was found in 10.9% of patients. For a cut-off value of 0.49, the APRI score predicted significant fibrosis with a sensitivity of 54%, a specificity of 93% and a negative predictive value of 94%. For a cut-off value of 1.01, the FIB-4 score predicted significant fibrosis with a sensitivity of 64%, a specificity of 84% and a negative predictive value of 95%. Performance of both scores was influenced by age, the body mass index, and cytolysis.

Conclusion: The APRI and FIB-4 scores had a good accuracy to exclude significant fibrosis in chronic hepatitis B virus infection.

StephenW

FIB4和APRI评分预测慢性乙型肝炎病毒感染患者纤维化的表现
Mouna Medhioub，Wafa Ben Salah，Amal Khsiba，Alaa Ouni，Lamine Hamzaoui，Mohamed Moussadek Azouz

    PMID：33480003

抽象

背景：肝纤维化的评估对于慢性乙型肝炎病毒感染的治疗至关重要。肝纤维化评估非侵入性测试的发展使得在某些情况下可以避免肝活检。

目的：评估在慢性乙型肝炎病毒感染中显着纤维化评估中APRI和FIB-4评分的表现。

方法：评估研究，包括接受肝活检的慢性乙型肝炎病毒感染患者。将APRI和FIB4用于检测明显纤维化的准确性与肝脏活检数据进行了比较。

结果：共纳入101例患者。在10.9％的患者中发现了明显的纤维化。截断值为0.49时，APRI评分预示着明显的纤维化，敏感性为54％，特异性为93％，阴性预测值为94％。对于1.01的临界值，FIB-4评分预测显着的纤维化，敏感性为64％，特异性为84％，阴性预测值为95％。两个评分的表现均受年龄，体重指数和细胞溶解的影响。

结论：APRI和FIB-4评分具有良