Peg-IFNα-2a有助于慢性乙型肝炎患者服用核酸类似物的HBs抗原

StephenW

Peg-IFNα-2a Contributed to HBs Antigen Seroclearance in a Patient with Chronic Hepatitis B Administered Nucleic Acid Analogs: A Three-year Follow-up
Tomoko Tadokoro  1 , Koji Fujita  1 , Kei Takuma  1 , Mai Nakahara  1 , Kyoko Oura  1 , Shima Mimura  1 , Teppei Sakamoto  1 , Takako Nomura  1 , Joji Tani  1 , Asahiro Morishita  1 , Hirohito Yoneyama  1 , Hideki Kobara  1 , Takashi Himoto  1 , Tsutomu Masaki  1
Affiliations
Affiliation

    1
    Department of Gastroenterology and Neurology, Kagawa University School of Medicine/Graduate School of Medicine, Japan.

    PMID: 33456036 DOI: 10.2169/internalmedicine.5783-20

Abstract

We treated a 51-year-old Japanese man with chronic hepatitis B (viral load 7.6 LC/mL, genotype C). HBV DNA and HBe antigen were undetectable during the administration of the nucleic acid analogs (NUCs) lamivudine and adefovir, although the concentration of HBs antigen (HBsAg) was 851.2 IU/mL. The HBsAg levels were reduced 150-fold when Peg-IFNα-2a was administered weekly for 48 weeks and did not increase during the rest period. Therefore, Peg-IFNα-2a was administered twice each week. During this time, HBsAg reached undetectable concentrations, and HBs antibody was detected and continued to be detectable during the three-year follow-up. These unprecedented findings suggest that IFN may contribute to the seroclearance of HBsAg in patients treated with NUCs.

Keywords: HBs antibody; HBs antigen; case reports; chronic hepatitis B; interferon.

StephenW

Peg-IFNα-2a有助于慢性乙型肝炎患者服用核酸类似物的HBs抗原血清清除：三年的随访。
ado子智子1，藤田康治1，筑波圭1，中原麻衣1，大浦恭子1，志摩三村1，坂本哲平1，野村孝子1，谷次二1，森下朝博1，米山裕人1，小原秀树1，高桥弘1，武藤正明1
隶属关系
联系

    1个
    日本香川大学医学院/研究生院胃肠病学和神经病学系。

    PMID：33456036 DOI：10.2169 / internalmedicine.5783-20

抽象

我们治疗了一名51岁的日本男子，患有慢性乙型肝炎（病毒载量7.6 LC / mL，基因型C）。 HBs DNA和HBe抗原在核酸类似物（NUCs）拉米夫定和阿德福韦给药期间无法检测到，尽管HBs抗原（HBsAg）浓度为851.2 IU / mL。每周施用Peg-IFNα-2a48周后，HBsAg水平降低了150倍，而在休息期间则没有升高。因此，每周两次施用Peg-IFNα-2a。在这段时间内，HBsAg达到了无法检测的浓度，并且在三年的随访期间检测到了HBs抗体并继续检测到。这些空前的发现表明，在NUCs治疗的患者中，IFN可能有助于HBsAg的血清清除。

关键字：HBs抗体； HBs抗原；病例报告；慢性乙型肝炎干扰素。

StephenW

https://www.jstage.jst.go.jp/art ... advpub_5783-20/_pdf