长时间工作与肝功能之间的横断面关联：Kangbuk三星健康研究

StephenW

Cross-sectional association between long working hours and liver function: the Kangbuk Samsung Health Study
Eunchan Mun  1 , Woncheol Lee  1 , Min-Woo Nam  1 , Hyun-Il Kim  1 , Hyeongcheol Kim  1 , Yesung Lee  1 , Soyoung Park  2   3
Affiliations
Affiliations

    1
    Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    2
    Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea [email protected].
    3
    Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

    PMID: 33376174 DOI: 10.1136/bmjopen-2020-041595

Abstract

Objectives: Although the effects of long working hours on liver function remain unclear, in South Korea, there is a social perception that long working hours are associated with poor liver function. Thus, long working hours have recently become a major issue. This study aimed to determine the association between long working hours and liver function, as indicated by the alanine transaminase (ALT) levels.

Design: Cross-sectional study.

Setting: Large university hospitals in Seoul and Suwon, South Korea.

Participants: Workers in formal employment who underwent a comprehensive health examination at the Kangbuk Samsung Hospital Total Healthcare Centre clinics in Seoul and Suwon, South Korea, between January 2011 and December 2018. Of the 386 488 participants, 212 421 met the inclusion criteria and were included in the analysis.

Primary outcome measure: ALT elevation.

Results: The participants were predominantly well-educated (86.1%), male (69.3%) and in their 30s (49.6%). In total, 13.4% of the participants presented ALT elevation (>40 IU/L). There was no significant association between working hours and ALT elevation in the general population and in the hepatitis B surface antigen (HBsAg)-negative group. Conversely, in the HBsAg-positive group, working >60 hours per week compared with 35-40 hours per week was significantly associated with ALT elevation. The association was more pronounced in those with ALT levels >80 IU/L (OR 1.94, 95% CI 1.24 to 3.01) than in those with ALT levels >40 IU/L (OR: 1.45, 95% CI 1.20 to 1.75). The p values for trend were <0.05.

Conclusions: Long working hours were associated with ALT elevation only in hepatitis B virus carriers and not in the general population. Provided that there is adherence to the legal working hours, there is no need to further restrict working hours for liver health, irrespective of HBsAg status.

Keywords: hepatology; occupational & industrial medicine; public health.

© Author(s) (or their employer(s)) 2020

StephenW

长时间工作与肝功能之间的横断面关联：Kangbuk三星健康研究
Eunchan Mun 1，Woncheol Lee 1，Min-Woo Nam 1，Hyun-Il Kim 1，Hyeongcheol Kim 1，Yesung Lee 1，Soyoung Park 2 3
隶属关系
隶属关系

    1个
    成均馆大学医学院江北三星医院职业与环境医学系，韩国首尔。
    2
    成均馆大学医学院江北三星医院职业与环境医学系，韩国首尔[email protected]。
    3
    韩国首尔成均馆大学医学院江北三星医院全面保健中心。

    PMID：33376174 DOI：10.1136 / bmjopen-2020-041595

抽象

目标：尽管尚不清楚长时间工作对肝功能的影响，但在韩国，社会上普遍认为长时间工作与肝功能差有关。因此，长时间的工作近来已成为主要问题。这项研究旨在确定长时间工作与肝功能之间的关联，如丙氨酸转氨酶（ALT）水平所示。

设计：横断面研究。

地点：韩国首尔和水原的大型大学医院。

参加者：在2011年1月至2018年12月之间在韩国首尔和水原的江北三星医院综合保健中心诊所接受了全面健康检查的正式就业工人。在386488名参与者中，有212421名符合入选标准，并且包含在分析中。

主要结果指标：ALT升高。

结果：参与者的受过良好教育（86.1％），男性（69.3％）和30多岁（49.6％）。总计有13.4％的参与者出现ALT升高（> 40 IU / L）。在普通人群和乙型肝炎表面抗原（HBsAg）阴性组中，工作时间与ALT升高之间没有显着相关性。相反，在HBsAg阳性组中，每周工作超过60小时而不是每周35-40小时与ALT升高显着相关。 ALT水平> 80 IU / L（OR 1.94，95％CI 1.24至3.01）的患者比ALT水平> 40 IU / L（OR：1.45，95％CI 1.20至1.75）的患者更明显。趋势的p值<0.05。

结论：长时间工作仅与乙型肝炎病毒携带者的ALT升高有关，而与普通人群无关。只要遵守法定的工作时间，就无需为肝脏健康而进一步限制工作时间，而与HBsAg状态无关。

关键字：肝病学；职业和工业医学；公共卫生。

©作者（或其雇主）2020

StephenW

https://bmjopen.bmj.com/content/bmjopen/10/12/e041595.full.pdf