恩替卡韋改善男性慢性乙型肝炎患者的生殖功能

StephenW

[Entecavir improves the reproductive function of male patients with chronic hepatitis B]
[Article in Chinese]
Yu-Fu Yu  1 , Yu Chen  2 , Xu-Feng Shen  2 , Rong-Jiang Wang  2 , Jun-Wen Shen  2 , Zhi-Hai Fang  2
Affiliations
Affiliations

    1
    Department of Urology, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang 311200, China.
    2
    Department of Urology, Huzhou First People's Hospital / The First Affiliated Hospital of Huzhou Normal College, Huzhou, Zhejiang 313100, China.

    PMID: 33351299

Abstract

Objective: To study the effect of entecavir on the reproductive function of male patients with chronic hepatitis B (CHB).

Methods: This study included 56 CHB male patients (aged 18－45 ［33.14 ± 5.38］ years) initially treated with entecavir at 0.5 mg/d for 24 weeks from 2015 to 2018 and another 24 healthy fertile male volunteers (aged 21－45 ［32.62 ± 5.94］ years) as normal controls. We obtained the body mass index (BMI), reproductive hormone levels, semen parameters and IIEF-5 scores from the subjects and compared them between the two groups before and after treatment.

Results: There were no statistically significant differences between the CHB and normal control groups in age, BMI, lifestyle and baseline reproductive hormone levels except in the levels of FSH (［3.92 ± 1.29］ vs ［3.08 ± 0.85］ mIU/ml, P = 0.003) and E2 (［35.79 ± 7.49］ vs ［28.25 ± 7.09］ pg/ml, P < 0.01). The semen parameters were significantly lower in the CHB patients than in the normal controls, including total sperm motility (［37.75 ± 13.33］% vs ［49.58 ± 9.27］%, P = 0.004), the percentage of progressively motile sperm (PMS) (［30.70 ± 10.03］% vs ［42.46 ± 8.90］%, P < 0.01), sperm concentration (［51.51 ± 19.50］ vs 70.33 ± 30.62) ×10⁶/ml, P = 0.007), and total sperm count (［160.2 ± 51.8］ vs ［225.91 ± 97.97］ ×106, P = 0.002), and so were the IIEF-5 scores (19.32 ± 2.34 vs 21.25 ± 2.35, P = 0.0006). After 24 weeks of entecavir treatment, the CHB patients showed no significant difference from the baseline in the semen volume, semen pH and days of abstinence, but remarkable improvement in total motility (［37.75 ± 13.33］ vs ［44.1 ± 11.89］%, P = 0.004), PMS (［30.70 ± 10.03］ vs ［38.30 ± 7.42］%, P < 0.01), sperm concentration (［51.51 ± 19.50］ vs ［62.00 ± 24.64］ ×10⁶/ml, P = 0.007), total sperm count (［160.21 ± 51.8］ vs ［207.65 ± 81.69］ ×106, P = 0.0002), and IIEF-5 score (20.13 ± 1.82 vs 19.32 ± 2.34, P = 0.02).

Conclusions: CHB patients have lower sexual function and semen quality than normal males. Entecavir can significantly improve the liver function, sexual function and semen quality of the CHB patients, but whether it directly improves the sexual function and semen quality of the patients or indirectly through liver function improvement needs to be further studied.

Keywords: antiviral therapy; entecavir; semen quality; chronic hepatitis B.

StephenW

恩替卡韋改善男性慢性乙型肝炎患者的生殖功能
[中文]
於玉福1，陳玉2，沉旭峰2，王榮江2，沉俊文2，方志海2
隸屬關係
隸屬關係

    1個
    浙江蕭山醫院泌尿外科，浙江杭州311200
    2
    湖州第一人民醫院/湖州師範學院第一附屬醫院泌尿外科，浙江湖州313100

    PMID：33351299

抽象

目的：研究恩替卡韋對男性慢性乙型肝炎（CHB）患者生殖功能的影響。

方法：本研究納入2015年至2018年最初接受0.5 mg / d恩替卡韋治療的56例CHB男性患者（18－45 ［33.14±5.38］歲），並於2015年至2018年進行了24周治療；另外24例健康的可育男性志願者（21 － 45歲） 32.62±5.94 ［年）作為正常對照。我們從受試者那裡獲得了體重指數（BMI），生殖激素水平，精液參數和IIEF-5評分，並比較了治療前後兩組之間的差異。

結果：除FSH水平外，CHB與正常對照組之間在年齡，BMI，生活方式和基線生殖激素水平上無統計學差異（［3.92±1.29］ vs ［3.08±0.85］ mIU / ml，P = 0.003）和E2（［35.79±7.49］ vs ［28.25±7.09］ pg / ml，P <0.01）。 CHB患者的精液參數顯著低於正常對照組，包括總精子活力（［37.75±13.33］％vs ［49.58±9.27］％，P = 0.004），進行性活動精子（PMS）的百分比（ ［30.70±10.03］％vs ［42.46±8.90］％，P <0.01），精子濃度（［51.51±19.50］ vs 70.33±30.62）×10⁶/ ml，P = 0.007），總精子數（［160.2± 51.8］ vs ［225.91±97.97］×106，P = 0.002），IIEF-5得分也是如此（19.32±2.34 vs 21.25±2.35，P = 0.0006）。恩替卡韋治療24週後，CHB患者的精液量，精液pH和禁慾天數與基線無顯著差異，但總運動能力明顯改善（［37.75±13.33］ vs ［44.1±11.89］％，P = 0.004），PMS（［30.70±10.03］ vs ［38.30±7.42］％，P <0.01），精子濃度（［51.51±19.50］ vs ［62.00±24.64］×10⁶/ ml，P = 0.007），總精子計數（［160.21±51.8］對［207.65±81.69］×106，P = 0.0002）和IIEF-5評分（20.13±1.82對19.32±2.34，P = 0.02）。

結論：CHB患者的性功能和精液質量均低於正常男性。恩替卡韋可以顯著改善CHB患者的肝功能，性功能和精液質量，但是它是直接改善患者的性功能和精液質量還是間接改善肝功能需要進一步研究。

關鍵詞：抗病毒治療；恩替卡韋精液質量慢性乙型肝炎

newchinabok

StephenW 发表于 2020-12-23 12:47
恩替卡韋改善男性慢性乙型肝炎患者的生殖功能
[中文]
於玉福1，陳玉2，沉旭峰2，王榮江2，沉俊文2，方志海2 ...

为了发帖子而发帖子，忘记了自己的初心了，为什么来这个论坛，想得到什么。

飞过沧海

感觉吃了替诺福韦之后，性功能直线下降，再也回复不到从前了。