免疫调节剂在乙肝病毒功能性治疗策略中的作用

StephenW

Role of Immunomodulators in Functional Cure Strategies for HBV

    Benedikt Binder, Maike Hofmann & Robert Thimme

Current Hepatology Reports volume 19, pages337–344(2020)Cite this article

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Abstract
Purpose of Review

Chronic Hepatitis B Virus (HBV) Infection is a major global health burden. Currently, a curative therapy does not exist; thus, there is an urgent need for new therapeutical options. Viral elimination in the natural course of infection results from a robust and multispecific T and B cell response that, however, is dysfunctional in chronically infected patients. Therefore, immunomodulatory therapies that strengthen the immune responses are an obvious approach trying to control HBV infection. In this review, we summarize the rationale and current options of immunological cure of chronic HBV infection.
Recent Findings

Recently, among others, drugs that stimulate the innate immune system or overcome CD8+ T cell exhaustion by checkpoint blockade, and transfer of HBV-specific engineered CD8+ T cells emerged as promising approaches.
Summary

HBV-specific immunity is responsible for viral control, but also for immunopathogenesis. Thus, the development of immunomodulatory therapies is a difficult process on a thin line between viral control and excessive immunopathology. Some promising agents are under investigation. Nevertheless, further research is indispensable in order to optimally orchestrate immunostimulation.

StephenW

免疫调节剂在乙肝病毒功能性治疗策略中的作用

    Benedikt Binder，Maike Hofmann和Robert Thimme

《当前肝病学报告》第19卷，第337–344页（2020年）

    205次访问

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抽象
审查目的

慢性乙型肝炎病毒（HBV）感染是全球主要的健康负担。目前，尚不存在治愈性疗法。因此，迫切需要新的治疗选择。病毒在自然感染过程中的消除是由于强大的多特异性T和B细胞反应引起的，但是在慢性感染的患者中功能失调。因此，增强免疫应答的免疫调节疗法是试图控制HBV感染的明显方法。在这篇综述中，我们总结了慢性乙肝病毒感染的免疫治疗的原理和当前的选择。
最近的发现

最近，除其他外，刺激先天免疫系统或通过检查点封锁克服CD8 + T细胞衰竭以及HBV特异性工程CD8 + T细胞转移的药物成为有前途的方法。
概要

HBV特异性免疫负责病毒控制，也负责免疫发病机理。因此，免疫调节疗法的发展是病毒控制与过度免疫病理学之间的一线难题。一些有前途的代理商正在调查中。然而，为了最佳地安排免疫刺激，进一步的研究是必不可少的。

StephenW

https://link.springer.com/conten ... 901-020-00538-6.pdf

newchinabok

StephenW 发表于 2020-12-21 19:32
https://link.springer.com/content/pdf/10.1007/s11901-020-00538-6.pdf

sw老师，免疫药太平庸，如果你用，也不一定有效果，所以对你来说，只有一条心磕药。