慢性乙型肝炎门诊患者甲胎蛋白水平与肝硬度的关系

StephenW

Association of alpha-fetoprotein levels with liver stiffness measurement in outpatients with chronic hepatitis B
Juan Wang  1 , Pengpeng Zhang  2 , Juan Liao  1 , Yan Zhu  1 , Xiaoli Liu  3 , Hong Tang  1
Affiliations
Affiliations

    1
    West China Hospital of Sichuan University, Chengdu, China.
    2
    The Third Xiangya Hospital, Central South University, Changsha, China.
    3
    Hunan Provincial Corps Hospital, Chinese People's Armed Police Forces, Changsha, China.

    PMID: 33289529 DOI: 10.1042/BSR20203048

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Abstract

The association between alpha-fetoprotein (AFP) levels with the assessment of liver stiffness (LS) in chronic hepatitis B (CHB) patients were explored. A total of 283 outpatients with CHB were enrolled. Patient age, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AFP, platelet (PLT), total bilirubin, direct bilirubin, alkaline phosphatase, albumin, globulin, and albumin/globulin (A/G) levels were associated with LS values in the univariate model (p<0.05). Significant associations between AFP and PLT levels with LS values were observed when both variables were included in the multivariate analysis models. Receiver operation characteristic (ROC) analysis indicated that the combination of AFP and PLT levels could enhance the predictive performance of liver fibrosis (AUC=0.819, p<0.001) and that PLT levels (PLT<100×10^9/L) combined with high AFP levels (AFP>8 ng/mL) significantly increased the prediction of liver fibrosis (OR=11.216). More importantly, LS values of associated with higher AFP levels (AFP >8 ng/mL), independently of higher ALT or AST values, were significantly higher than those of low AFP level groups. In conclusion, in Chinese outpatients with CHB, AFP outperformed ALT and/or AST levels in terms of their association with LS. AFP and PLT levels were independently associated with LS, and their combined assessment could enhance the diagnostic and predictive performance of liver fibrosis among CHB patients.

Keywords: AFP; chronic hepatitis B; liver fibrosis; liver stiffness measurement.

Copyright 2020 The Author(s).

StephenW

慢性乙型肝炎门诊患者甲胎蛋白水平与肝硬度的关系
王娟1，张鹏鹏2，廖娟1，朱彦1，刘晓丽3，红堂1
隶属关系
隶属关系

    1个
    四川大学华西医院，成都
    2
    中南大学湘雅三医院，长沙
    3
    中国人民武装警察部队湖南省兵团医院，长沙

    PMID：33289529 DOI：10.1042 / BSR20203048

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抽象

探讨了甲胎蛋白（AFP）水平与慢性乙型肝炎（CHB）患者肝硬度（LS）评估之间的关系。共有283名CHB门诊患者入选。患者年龄，丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST），AFP，血小板（PLT），总胆红素，直接胆红素，碱性磷酸酶，白蛋白，球蛋白和白蛋白/球蛋白（A / G）水平与LS值相关在单变量模型中（p <0.05）。当两个变量都包含在多变量分析模型中时，观察到AFP和PLT水平与LS值之间的显着关联。接受者操作特征（ROC）分析表明，AFP和PLT水平的结合可以增强肝纤维化的预测性能（AUC = 0.819，p <0.001），而PLT水平（PLT <100×10 ^ 9 / L）可以提高肝纤维化的预测性能。高AFP水平（AFP> 8 ng / mL）显着提高了肝纤维化的预测（OR = 11.216）。更重要的是，与较高的AFP水平相关的LS值（AFP> 8 ng / mL），与较高的ALT或AST值无关，明显高于低AFP水平组。总之，在中国患有CHB的门诊患者中，AFP与LS的相关性优于ALT和/或AST水平。 AFP和PLT水平与LS独立相关，它们的联合评估可以增强CHB患者肝纤维化的诊断和预测性能。

关键字：法新社；慢性乙型肝炎肝纤维化肝硬度测量。

版权所有2020作者。

StephenW

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