乙型肝炎核心蛋白衣殼

StephenW

Hepatitis B Core Protein Capsids
Bettina Böttcher  1
Affiliations
Affiliation

    1
    Rudolf Virchow Center and Biocenter, Julius Maximilians Universität Würzburg, Josef-Schneider Straße 2, 97080, Würzburg, Germany. [email protected].

    PMID: 33252740 DOI: 10.1007/978-3-030-58971-4_14

Abstract

Non-enveloped Nackednaviridae and enveloped hepadnaviridae both have capsids that are formed by related small proteins which evolved more than 430 Mya. In Hepatitis B virus, which belongs to the enveloped hepadnaviridae, this small protein is termed Hepatitis B core protein (Hbc). Its function, as building block of a major human pathogen, triggered extensive research that elucidated the importance of almost every single amino acid for the structural integrity of the capsids and the orderly progression of the viral life cycle. In particular, encapsidation of the genome, envelopment of the capsid, uncoating of the genome and targeting of the different compartments during viral maturation have been a vivid focus of research. HBc has also been developed as a biotechnological tool for the design of nano-containers with tailored properties. These nano-containers can display foreign epitopes on their surfaces and induce a strong immune response, which is attractive for the development of vaccines against other pathogens. This chapter will discuss some of the unique properties of HBc and their significance for the formation of a functional macromolecular capsid.

Keywords: Arginine-rich domain; Assembly domain; C-terminal domain; Hepatitis B core protein; Hepatitis B virus; Icosahedral capsid; Nano-container; Spike.

StephenW

乙型肝炎核心蛋白衣殼
貝蒂娜·伯切（BettinaBöttcher）1
隸屬關係
聯繫

    1個
    維爾茨堡朱利葉斯·馬克西米利安斯大學Rudolf Virchow中心和生物中心，約瑟夫·施耐德大街2號，郵政編碼97080，德國維爾茨堡。 [email protected]。

    PMID：33252740 DOI：10.1007 / 978-3-030-58971-4_14

抽象

非包膜的Nackednaviridae和包膜的hepadnaviridae都具有由相關小蛋白形成的衣殼，這些蛋白進化出430多個Mya。在屬於被包膜的嗜肝病毒科的乙型肝炎病毒中，這種小蛋白被稱為乙型肝炎核心蛋白（Hbc）。其功能作為主要人類病原體的組成部分，引發了廣泛的研究，闡明了幾乎每個氨基酸對衣殼的結構完整性和病毒生命週期的有序發展的重要性。特別地，在病毒成熟過程中，基因組的衣殼化，衣殼的包裹，基因組的脫殼以及針對不同區室的靶向已成為研究的重點。 HBc也已被開發為一種生物技術工具，用於設計具有定制性能的納米容器。這些納米容器可以在其表面上顯示外來抗原決定簇並誘導強烈的免疫反應，這對於開發針對其他病原體的疫苗具有吸引力。本章將討論HBc的一些獨特特性及其對功能性大分子衣殼形成的意義。

關鍵詞：富含精氨酸的結構域；組裝領域； C端結構域；乙型肝炎核心蛋白；乙型肝炎病毒;二十面體衣殼;納米容器穗。