乙型肝炎病毒誘發肝癌發生的機制

StephenW

Mechanisms of Hepatitis B Virus-Induced Hepatocarcinogenesis
Jiyoung Lee  1 , Kuen-Nan Tsai  1 , Jing-Hsiung James Ou  2
Affiliations
Affiliations

    1
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, 2011 Zonal Avenue, HMR-401, Los Angeles, CA, 90033, USA.
    2
    Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, 2011 Zonal Avenue, HMR-401, Los Angeles, CA, 90033, USA. [email protected].

    PMID: 33200361 DOI: 10.1007/978-3-030-57362-1_3

Abstract

Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). There are approximately 250 million people in the world that are chronically infected by this virus, resulting in nearly 1 million deaths every year. Many of these patients die from severe liver diseases, including HCC. HBV may induce HCC through the induction of chronic liver inflammation, which can cause oxidative stress and DNA damage. However, many studies also indicated that HBV could induce HCC via the alteration of hepatocellular physiology that may involve genetic and epigenetic changes of the host DNA, the alteration of cellular signaling pathways, and the inhibition of DNA repair mechanisms. This alteration of cellular physiology can lead to the accumulation of DNA damages and the promotion of cell cycles and predispose hepatocytes to oncogenic transformation.

StephenW

乙型肝炎病毒誘發肝癌發生的機制
李繼英1，蔡冠南1，歐景雄2
隸屬關係
隸屬關係

    1個
    南加州大學凱克醫學院分子微生物學和免疫學系，2011 Zonal Avenue，HMR-401，Los Angeles，CA，90033，USA。
    2
    南加州大學凱克醫學院分子微生物學和免疫學系，2011 Zonal Avenue，HMR-401，Los Angeles，CA，90033，USA。 [email protected]。

    PMID：33200361 DOI：10.1007 / 978-3-030-57362-1_3

抽象

乙型肝炎病毒（HBV）是肝細胞癌（HCC）的主要原因。世界上大約有2.5億人長期被這種病毒感染，每年導致近100萬人死亡。這些患者中許多死於包括HCC在內的嚴重肝臟疾病。 HBV可能通過誘導慢性肝炎來誘導HCC，這可以引起氧化應激和DNA損傷。但是，許多研究還表明，HBV可以通過改變肝細胞生理學（包括宿主DNA的遺傳和表觀遺傳學改變），改變細胞信號通路以及抑制DNA修復機制來誘導HCC。細胞生理學的這種改變可導致DNA損傷的積累和細胞週期的促進，並使肝細胞易於致癌轉化。