乙肝病毒感染和糖尿病：中国开lu前瞻性队列研究

StephenW

Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China

    Shaoyuan Lei, Shuohua Chen, Xinyu Zhao, Yanmin Zhang, Kailiang Cheng, Xiaohui Zhang, Zhenyu Wang, Yuanyuan Sun, Shouling Wu & Li Wang

Hepatology International volume 14, pages743–753(2020)Cite this article

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Abstract
Background and aims

The effect of hepatitis B virus (HBV) infection on diabetes has remained unclear. We thus conducted a prospective cohort study to investigate the association between different HBV infection status and new-onset diabetes in a Chinese population.
Methods

We enrolled 55,520 participants with HBV serological markers and diabetes free in 2010 in Kailuan cohort. Cox regression models were used to analyze the relationship between different HBV infection status and incidence of diabetes after adjusting different confounders.
Results

During an average follow-up of 5.6 years, we identified 6008 incident patients with diabetes. Compared to the participants with hepatitis B surface antigen (HBsAg) negative/hepatitis B surface antibody (anti-HBs) negative/hepatitis B core antibody (anti-HBc) negative, those with chronic HBV infection or with HBsAg negative/anti-HBc positive had a higher risk to occur diabetes. The hazard ratios were 1.18 (95% CI 0.99–1.40, p = 0.0588) and 1.22 (95% CI 1.08–1.36, p = 0.0009), respectively. The association between chronic HBV infection, anti-HBc positive and diabetes was different between those with different levels of high density lipoprotein cholesterol, blood pressure, body mass index, and age.
Conclusion

The individuals with chronic HBV infection or anti-HBc positive may have an increased risk of diabetes, and the association may be modified by the different status of metabolism related variables and age. Effective management of HBV infection may contribute to the reduction of the burden of both hepatitis B and diabetes.

StephenW

乙肝病毒感染和糖尿病：中国开lu前瞻性队列研究

    雷少元，陈硕华，赵新宇，张艳敏，程凯良，张晓辉，王振宇，孙元元，吴寿玲和王丽

《国际肝病学》第14卷，743-753页（2020年）

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抽象
背景和目标

乙肝病毒（HBV）感染对糖尿病的影响尚不清楚。因此，我们进行了一项前瞻性队列研究，以调查中国人群中不同的HBV感染状况与新发糖尿病之间的关系。
方法

2010年，我们在开lu队列研究中招募了55,520名无HBV血清学标志物和糖尿病的参与者。校正不同的混杂因素后，使用Cox回归模型分析不同HBV感染状况与糖尿病发生率之间的关系。
结果

在平均5.6年的随访中，我们确定了6008名糖尿病患者。与乙型肝炎表面抗原（HBsAg）阴性/乙型肝炎表面抗体（抗HBs）阴性/乙型肝炎核心抗体（抗HBc）阴性的参与者，慢性HBV感染或HBsAg阴性/抗HBc阳性的参与者相比发生糖尿病的风险更高。危险比分别为1.18（95％CI 0.99-1.40，p = 0.0588）和1.22（95％CI 1.08-1.36，p = 0.0009）。高密度脂蛋白胆固醇，血压，体重指数和年龄不同的人群之间，慢性HBV感染，抗-HBc阳性和糖尿病之间的相关性有所不同。
结论

患有慢性HBV感染或抗HBc阳性的个体患糖尿病的风险可能会增加，并且这种关联可能会因新陈代谢相关变量和年龄的不同状态而改变。有效管理HBV感染可能有助于减轻乙型肝炎和糖尿病的负担。