咖啡摄入量增加可能降低与肝有关的死亡风险

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Increased Coffee Intake May Lower Risk of Liver-Related Death

Researchers found that more than 700,000 fewer people would die if the per capita coffee consumption were four or more cups per day.

October 14, 2020 • By Sukanya Charuchandra

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Increasing coffee consumption from about two cups to four or more cups per day across the population could help reduce deaths from liver disease, according to a study published in Alimentary Pharmacology and Therapeutics.  



“This current paper estimates that nearly half a million lives may be able to be saved annually if moderate coffee drinking became embraced globally as a health initiative to reduce the risk of

premature death from liver disease,” wrote the study authors.



Hepatitis B and C, fatty liver disease, heavy alcohol use and other causes of liver injury can lead to cirrhosis, liver cancer and end-stage liver failure. Globally, cirrhosis causes more than a million deaths, accounting for some 2% of all deaths each year.  



Earlier studies have linked coffee consumption with better liver function and slower development of cirrhosis. A dose-related positive effect on death from liver-related causes has also been reported.  



Paul Gow, MD, of Austin Health and the University of Melbourne in Australia, and colleagues conducted a study to determine the effect of drinking more coffee on worldwide mortality from liver disease.  



The team used data from the 2016 Global Burden of Disease study and mathematical modeling to analyze the impact of increasing coffee consumption per person on liver-related death across 112 countries for which coffee consumption data were available. The data set included information on men and women over age 15 and the number of deaths due to hepatitis B and other liver disease in 2016.  



In 2016, around 1,240,201 adults worldwide died of liver-related causes. At the same time, the median global liver-related death rate was 15 deaths per 100,000 people per year.  



The researchers found that if the per capita coffee intake in nations in which people drank at most two cups of coffee per day on average had instead been more than two cups per day, the estimated number of liver-related deaths would have been 630,947, with 452,861 fewer people dying in 2016. If the average per capita intake had been four cups per day, the estimated number would have been 360,523, with 723,287 fewer people dying.  



While these results were statistically significant, more studies are needed to confirm and advance this finding.  

  
“Based on available data, coffee represents a simple, relatively safe and accessible public health intervention that may reduce liver-related mortality globally,” wrote the authors. “If the impact of coffee on liver-related mortality shown in cohort studies is confirmed in clinical trials, increasing per capita coffee consumption to more than two cups per capita per day on a population level has the potential to avert hundreds of thousands of deaths from liver disease annually.”  



Click here to read the study in Alimentary Pharmacology and Therapeutics.

StephenW

咖啡摄入量增加可能降低与肝有关的死亡风险

研究人员发现，如果人均每天喝四杯或更多杯咖啡，将有70万多人丧生。

2020年10月14日•Sukanya Charuchandra发表

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根据《 Alimentary Pharmacology and Therapeutics》发表的一项研究，在整个人群中，每天将咖啡消耗量从大约两杯增加到四杯或更多，可以帮助减少因肝脏疾病而导致的死亡。



“目前的论文估计，如果全球范围内普遍采用适量的咖啡饮用以减少健康风险，每年可以挽救近一百万人的生命。

肝病过早死亡”，研究作者写道。



乙型和丙型肝炎，脂肪肝疾病，大量饮酒和其他肝损伤原因可导致肝硬化，肝癌和晚期肝衰竭。在全球范围内，肝硬化导致超过100万人死亡，每年约占所有死亡人数的2％。



早期的研究将饮用咖啡与更好的肝功能和较慢的肝硬化联系起来。也已经报道了与剂量相关的对肝相关原​​因死亡的积极作用。



澳大利亚奥斯汀健康大学和墨尔本大学的医学博士Paul Gow及其同事进行了一项研究，以确定多喝咖啡对全世界肝病死亡率的影响。



该团队使用2016年全球疾病负担研究和数学模型得出的数据，分析了在112个可提供咖啡消费数据的国家中，人均咖啡摄入量增加对肝脏相关死亡的影响。该数据集包括2016年15岁以上男性和女性的信息以及因乙型肝炎和其他肝病导致的死亡人数。



2016年，全世界约有1,240,201名成年人死于肝脏相关原因。同时，全球与肝脏相关的死亡率中位数为每年每100,000人中15例死亡。



研究人员发现，如果在那些平均每天最多喝两杯咖啡的国家中，人均咖啡摄入量却超过每天两杯，那么与肝脏有关的死亡人数估计将为630,947，其中2016年，死亡人数减少了452,861人。如果人均每天摄入4杯咖啡，则估计人数将为360,523，死亡人数减少723,287。



尽管这些结果具有统计意义，但仍需要进行更多研究以证实和推进这一发现。

  
这组作者写道：“根据现有数据，咖啡代表一种简单，相对安全且可访问的公共卫生干预措施，可在全球范围内降低与肝脏相关的死亡率。” “如果在临床试验中证实了咖啡对队列研究中显示的与肝有关的死亡率的影响，则将人均咖啡消费量提高到人均每天两杯以上，有可能避免数十万人死于每年都有肝脏疾病。”



单击此处以阅读《消化药理学和治疗学》中的研究。