乙肝发作的再治疗决定

StephenW

Retreatment decision for hepatitis B flare
Yun-Fan Liaw  1
Affiliations
Affiliation

    1
    Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.

    PMID: 33020909 DOI: 10.1002/hep.31586

Abstract

The point of liver biopsy for significant inflammation and/or fibrosis may be important for patients with normal ALT but not for hepatitis flare (ALT elevation >5 times upper limit of normal). Since hepatitis flares has been considered as results of endogenous immune response against HBV, patients with hepatitis flare are associated with different degree of significant necroinflammatory activity. The most important step of management for patients with hepatitis flare is to ensure safety that is to prevent hepatic decompensation, especially in patients with advanced fibrosis, and to treat patients with overt hepatic decompensation immediately [2].

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乙肝发作的再治疗决定
廖云凡1
隶属关系
联系

     1
     台湾台北市长庚大学医学院长庚纪念医院肝脏研究室。

     PMID：33020909 DOI：10.1002 / hep.31586

抽象

对于ALT正常的患者，肝活检点对于重要的炎症和/或纤维化可能很重要，而对于肝炎发作（ALT升高>正常上限的5倍）则不重要。 由于肝炎爆发已被认为是针对HBV的内源性免疫反应的结果，因此患有肝炎爆发的患者具有不同程度的重要坏死性炎症活动。 肝炎发作患者最重要的管理步骤是确保安全，防止肝代偿失调，尤其是晚期纤维化患者，并立即治疗明显肝代偿失调的患者[2]。

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