云南省15461名孕妇中乙型肝炎病毒感染率及其相关因素

StephenW

Prevalence of hepatitis B virus infection and its associated factors among 15,461 pregnant women in Yunnan province, China
Jihong Liu  1 , Jue Liu  2 , Min Liu  3 , Qian Pang  1 , Ying Wen  1
Affiliations
Affiliations

    1
    Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University, Kunmin City, Yunnan, China.
    2
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China. Electronic address: [email protected].
    3
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China.

    PMID: 32951803 DOI: 10.1016/j.annepidem.2020.05.011

Abstract

Purpose: China has the world's largest burden of hepatitis B virus (HBV) infection. However, there are few studies reported on the latest prevalence of hepatitis B surface antigen (HBsAg) among pregnant women in China. We aimed to assess the prevalence of HBV infection and its associated risk factors among pregnant women in Yunnan, which is a province with relatively high prevalence of blood-borne viruses.

Methods: We conducted a cross-sectional study of 15,641 pregnant women who underwent routine antenatal screening for HBsAg in Yunnan between 2013 and 2016. Logistic regression analyses were used to examine the associations between HBV infection and risk factors.

Results: Overall, 7.89% (95% confidence interval (CI), 7.47%-8.31%) of the 15,641 pregnant women tested positive for HBsAg. Multivariable logistic regression analysis showed that advanced age (≥35 years old; adjusted odds ratio [aOR], 2.43-2.59), Hani ethnicity (aOR, 1.97; 95% CI, 1.22-3.17), unemployed women (aOR, 1.88; 95% CI, 1.30-2.72), multigravidas (aOR, 1.21; 95% CI, 1.05-1.40), and multiparas (aOR, 1.28; 95% CI, 1.10-1.49) were more likely to be infected with HBV. HBV infection was associated with cesarean section and preterm birth, with aORs of 1.31 (1.17-1.48) and 1.23 (1.00-1.51), respectively. In the subgroup analysis, the association between Hani ethnicity and HBV infection was significantly higher in women aged 35 years or older (aOR = 5.15; 95% CI, 1.51-17.55) than in women younger than 35 years of age (aOR = 1.69; 95% CI, 1.00-2.86).

Conclusions: HBV infection among 15,641 pregnant women was of high-intermediate endemicity in Yunnan, China. Advanced age, Hani ethnicity, unemployment, and multigravid and multiparous statuses were associated with an increased prevalence of HBV infection. High-risk pregnant women should be paid more attention during routine antenatal examination.

Keywords: China; Epidemiology; Hepatitis B virus; Pregnant women.

Copyright © 2020 Elsevier Inc. All rights reserved.

StephenW

云南省15461名孕妇中乙型肝炎病毒感染率及其相关因素
刘继红1，刘觉2，刘敏3，钱庞1，迎文1
隶属关系
隶属关系

    1个
    昆明医科大学附属第二医院妇产科，云南昆明。
    2
    北京大学健康科学中心公共卫生学院流行病学和生物统计学系，北京。电子地址：[email protected]。
    3
    北京大学健康科学中心公共卫生学院流行病学和生物统计学系，北京。

    PMID：32951803 DOI：10.1016 / j.annepidem.2020.05.011

抽象

目的：中国承担着世界上最大的乙肝病毒感染负担。但是，关于中国孕妇中最新的乙型肝炎表面抗原（HBsAg）患病率的报道很少。我们旨在评估在云南省孕妇中的乙肝病毒感染率及其相关危险因素，该省是血传播病毒流行率较高的省。

方法：我们对2013年至2016年间在云南省进行常规产前筛查HBsAg的15,641名孕妇进行了横断面研究。采用逻辑回归分析检查了HBV感染与危险因素之间的关系。

结果：总体而言，在15641名孕妇中HBsAg呈阳性反应的占7.89％（95％置信区间（CI），7.47％-8.31％）。多变量logistic回归分析显示，高龄（≥35岁;调整后的优势比[aOR]为2.43-2.59），哈尼族（aOR为1.97; 95％CI为1.22-3.17），失业妇女（aOR为1.88; 95） ％CI（1.30-2.72），多胎（aOR，1.21; 95％CI，1.05-1.40）和多对分体（aOR，1.28; 95％CI，1.10-1.49）更有可能感染HBV。 HBV感染与剖宫产和早产相关，aOR分别为1.31（1.17-1.48）和1.23（1.00-1.51）。在亚组分析中，年龄在35岁以上的女性（aOR = 5.15； 95％CI，1.51-17.55）与35岁以下的女性（aOR = 1.69； 35岁或以上）之间的哈尼族裔和HBV感染之间的关联性显着更高。 95％CI，1.00-2.86）。

结论：云南省15641名孕妇中HBV感染属于高中流行。高龄，哈尼族，失业，多重和多胎状态与HBV感染患病率增加有关。高危孕妇应在常规产前检查中给予更多关注。

关键字：中国；流行病学；乙型肝炎病毒;孕妇

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