細胞自噬和乙型肝炎病毒複製之間的相互作用：系統評價

StephenW

Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review
Yong Lin  1 , Zhenyu Zhao  1 , Ailong Huang  1 , Mengji Lu  2
Affiliations
Affiliations

    1
    Key Laboratory of Molecular Biology of Infectious Diseases (Chinese Ministry of Education), The Second Affiliated Hospital, Institute for Viral Hepatitis, Chongqing Medical University, Chongqing 400016, China.
    2
    Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.

    PMID: 32942717 DOI: 10.3390/cells9092101

Abstract

Autophagy, a conserved process in which cells break down and destroy old, damaged, or abnormal proteins and other substances in the cytoplasm through lysosomal degradation, occurs via autophagosome formation and aids in the maintenance of intracellular homeostasis. Autophagy is closely associated with hepatitis B virus (HBV) replication and assembly. Currently, HBV infection is still one of the most serious public health issues worldwide. The unavailability of satisfactory therapeutic strategies for chronic HBV infection indicates an urgent need to elucidate the mechanisms underlying the pathogenesis of HBV infection. Increasing evidence has shown that HBV not only possesses the ability to induce incomplete autophagy but also evades autophagic degradation, indicating that HBV utilizes or hijacks the autophagy machinery for its own replication. Therefore, autophagy might be a crucial target pathway for controlling HBV infection. The definite molecular mechanisms underlying the association between cellular autophagy and HBV replication require further clarification. In this review, we have summarized and discussed the latest findings on the interplay between autophagy and HBV replication.

Keywords: HBs; HBx; autophagosome; autophagy; hepatitis B virus; viral replication.

StephenW

細胞自噬和乙型肝炎病毒複製之間的相互作用：系統評價。
雍林1，趙振宇1，黃愛龍1，孟吉路2
隸屬關係
隸屬關係

    1個
    重慶醫科大學附屬第二醫院病毒性肝炎研究所，傳染病分子生物學教育部重點實驗室（中國教育部），重慶400016
    2
    杜伊斯堡－埃森大學埃森大學醫院病毒研究所，德國埃森45122。

    PMID：32942717 DOI：10.3390 / cells9092101

抽象

自噬是一種保守的過程，其中細胞通過溶酶體降解而分解並破壞細胞質中的舊的，受損的或異常的蛋白質和其他物質，通過自噬小體形成，並有助於維持細胞內穩態。自噬與乙型肝炎病毒（HBV）的複制和組裝密切相關。目前，HBV感染仍然是全世界最嚴重的公共衛生問題之一。無法獲得令人滿意的慢性HBV感染治療策略表明，迫切需要闡明HBV感染髮病機理的機制。越來越多的證據表明，HBV不僅具有誘導不完全自噬的能力，而且還具有逃避自噬降解的能力，這表明HBV利用或劫持自噬機制進行自身複製。因此，自噬可能是控制HBV感染的關鍵靶途徑。細胞自噬和HBV複製之間關聯的確切分子機制需要進一步闡明。在這篇綜述中，我們總結並討論了自噬與HBV複製之間相互作用的最新發現。

關鍵字：乙肝； HBx;自噬體自噬乙型肝炎病毒;病毒複製。

StephenW

https://www.mdpi.com/2073-4409/9/9/2101/pdf