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Biomarkers for hepatitis B virus replication an overview and a look to the future.
Feng-Cai Li , Yue-Kai Li & Yu-Chen Fan ORCID Icon
Received 09 May 2020, Accepted 24 Aug 2020, Accepted author version posted online: 04 Sep 2020
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Accepted author version
Abstract
Introduction
Hepatitis B virus(HBV) infection is a major public health issue but there are no powerful drugs to eradicate the virus. HBV markers including HBsAg, HBcrAg, HBV RNA, HBcAb and HBV DNA are becoming promising biomarkers to reflect the natural phases of chronic HBV infection and predict the outcome of anti-HBV treatment.
Areas covered
The authors summarized the biomarkers of HBV replication and presented the current advances of these biomarkers on predicting the outcome of anti-HBV treatment and identifying the progression of chronic HBV infection.
Expert opinion
HBsAg, HBcrAg, HBV RNA, HBcAb and HBV DNA are noninvasive and feasible biomarkers for monitoring the process of anti-HBV therapy and predicting the progress of HBV infection. However, there are still no strong biomarkers with high sensitivity and specificity for clinical application. Combination of two or more HBV biomarkers, new technique for measuring HBV cccDNA, and searching novel HBV biomarkers are essential for anti-HBV treatment in the future.
Keywords: Hepatitis B Virus, Biomarker, Covalently closed circular DNA, HBcrAg, HBV RNA, HBsAg, HBcAb, HBV DNA, Immune stages |
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发表于 2020-9-5 20:56