乙肝核心相关抗原水平可预测HBV相关早期肝细胞癌患者的无

StephenW

Hepatitis B core-related antigen levels predict recurrence-free survival in patients with HBV associated early stage hepatocellular carcinoma: results from a Dutch long-term follow-up study
Boris J B Beudeker  1 , Zwier M A Groothuismink  1 , Robert A de Man  1 , Caroline D M Witjes  2 , Annemiek A van der Eijk  3 , Andre Boonstra  1 , Milan J Sonneveld  1
Affiliations
Affiliations

    1
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
    2
    Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
    3
    Department of Viroscience, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

    PMID: 32869922 DOI: 10.1111/jvh.13394

Abstract

Prognosis of hepatitis B (HBV) associated hepatocellular carcinoma (HCC) is poor due to high rates of HCC recurrence and progression of underlying liver disease. We studied whether serum hepatitis B core related antigen (HBcrAg) levels could predict HCC recurrence and outcome in HBV associated. Higher HBcrAg levels at HCC diagnosis were independently associated with reduced overall and recurrence-free survival in patients with early, but not advanced, stage HCC.

Keywords: HBcrAg; Hepatitis B; hepatocellular carcinoma; survival.

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StephenW

乙肝核心相关抗原水平可预测HBV相关早期肝细胞癌患者的无复发生存：荷兰长期随访研究的结果
Boris J B Beudeker 1，Zwier M A Groothuismink 1，Robert A de Man 1，Caroline D M Witjes 2，Annemiek A van der Eijk 3，Andre Boonstra 1，Milan J Sonneveld 1
隶属关系
隶属关系

    1个
    荷兰鹿特丹伊拉斯姆斯MC大学医学中心胃肠病学和肝病学系。
    2
    荷兰鹿特丹伊拉斯姆斯MC大学医学中心外科。
    3
    荷兰鹿特丹伊拉斯姆斯MC大学医学中心病毒学系。

    PMID：32869922 DOI：10.1111 / jvh.13394

抽象

乙型肝炎（HBV）相关的肝细胞癌（HCC）的预后较差，原因是HCC复发率高和潜在的肝病进展。我们研究了血清乙肝核心相关抗原（HBcrAg）水平是否可以预测HCC复发和HBV相关结局。肝癌早期诊断中较高的HBcrAg水平与早期（但不是晚期）肝癌患者的总体生存率和无复发生存率独立相关。

关键字：HBcrAg;乙型肝炎；肝细胞癌；生存。

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