花粉过敏疫苗显示出能防止乙肝病毒进入肝细胞的能力

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草花粉过敏疫苗在人体中所产生的抗体在细胞模型中显示出防止乙肝病毒进入肝细胞系的功效

https://www.sciencedirect.com/science/article/pii/S2352396416303292?via%3Dihub

Allergy vaccine candidate BM32 is scheduled for 2021 approval
BM32 疫苗（用于治疗花粉过敏）目前在3期临床。



Highlights
•BM32 is a recombinant allergy vaccine consisting of the preS domain of the large envelope protein of hepatitis B virus (HBV) and allergen-derived peptides.

•Vaccination of allergic patients with BM32 induced preS-specific antibodies which inhibit hepatitis B infection in vitro.

•BM32 may be useful as therapeutic vaccine in HBV-infected patients.

Infection with HBV remains a major cause of morbidity and mortality worldwide. Conventional HBV vaccines, consisting of SHBs particles solely, do not elicit adequate antibody production in 5–10% of vaccines and there is a need for therapeutic HBV vaccines. We have engineered an allergy vaccine which consists of allergen-derived peptides fused to the preS domain of the large envelope protein of HBV. Here we show that vaccination of allergic patients with this vaccine induces antibodies which protect against HBV infection in vitro. The preS-containing allergy vaccine may thus be also useful for therapeutic vaccination of HBV-infected patients.