咖啡與肝癌發展的逆相關性：更新的系統評價和薈萃分析

StephenW

Inverse Association of Coffee with Liver Cancer Development: An Updated Systematic Review and Meta-analysis
Abhishek Bhurwal  1 , Puru Ratta  2 , Sho Yoshitake  3 , Lauren Pioppo  4 , Debashish Reja  5 , Peter Dellatore  6 , Vinod Rustgi  7
Affiliations
Affiliations

    1
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. . [email protected].
    2
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. [email protected].
    3
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. [email protected].
    4
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. [email protected].
    5
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. [email protected].
    6
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. [email protected].
    7
    Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of Medicine, New Brunswick, NJ Center for Liver Diseases and Liver Masses, New Brunswick, NJ, USA. [email protected].

    PMID: 32830818 DOI: 10.15403/jgld-805

Abstract

Background and aims: Coffee consumption has been suggested to reduce the risk for hepatocellular carcinoma (HCC). While several studies report inverse correlation with coffee drinking, others have suggested more than 2 cups of coffee every day decrease the risk of liver cancer or HCC. However, controversy exists about the exact dose that would provide protective benefit. Therefore, we aimed to carry out a systematic review and meta-analysis of all studies that investigated the association of coffee consumption and risk of HCC and/or liver cancer. Our outcomes were the evaluation of the association of coffee with HCC or liver cancer development along with the amount of coffee needed to prevent HCC or liver cancer.

Methods: We performed a PubMed/MEDLINE/EMBASE/Ovid/Google Scholar search of original articles published in English from 1996 to June 2019, on case-control or cohort or prospective studies that associated coffee with liver cancer or HCC. We calculated the relative risk (RR) of the two conditions for coffee drinking and then stratified this into increments of one cup of coffee per day. Twenty studies were identified. The analysis was performed using random effects models from the methods of DerSimonian and Laird with inverse variance weighting. The Cochrane Q and the I 2 statistics were calculated to assess heterogeneity between studies. A p<0.10 value for chi-square test and I 2 <20% were interpreted as low-level heterogeneity. Probability of publication bias was assessed using funnel plots and with the Egger's test.

Results: The overall RR was 0.69 (95%CI 0.56-0.85; p<0.001) with significant heterogeneity between the studies. We performed subgroup analysis over the increments of 1 cup of coffee. Higher doses of coffee consumption were associated with a significant decrease in the risks of developing HCC or liver cancer. The funnel plot did not show significant publication bias.

Conclusions: Our systematic review and meta-analysis suggests that drinking coffee provides benefits with a reduction in the risk of HCC or liver cancer. Higher doses of coffee have higher benefits in terms of risk reduction. However, further biological and epidemiological studies are required to determine the exact mechanism and to study specific subgroups such as viral hepatitis B or C related HCC.

StephenW

咖啡與肝癌發展的逆相關性：更新的系統評價和薈萃分析
Abhishek Bhurwal 1，Puru Ratta 2，Sho Yoshitake 3，Lauren Pioppo 4，Debashish Reja 5，Peter Dellatore 6，Vinod Rustgi 7
隸屬關係
隸屬關係

    1個
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克市羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學部。 。 [email protected]。
    2
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克市羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學部。 [email protected]。
    3
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克省羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學分部。 [email protected]。
    4
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克省羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學部。 [email protected]。
    5
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克省羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學部。 [email protected]。
    6
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克省羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學分部。 [email protected]。
    7
    美國新澤西州新不倫瑞克省新澤西州新不倫瑞克省羅格斯大學羅伯特伍德·約翰遜醫學院胃腸病學和肝病學分部。 [email protected]。

    PMID：32830818 DOI：10.15403 / jgld-805

抽象

背景和目的：已建議喝咖啡以降低患肝細胞癌（HCC）的風險。儘管有幾項研究報告說與喝咖啡成反比，但另一些研究則建議每天喝兩杯以上的咖啡可以降低患上肝癌或肝癌的風險。但是，關於提供保護益處的確切劑量存在爭議。因此，我們旨在對所有調查咖啡消費與HCC和/或肝癌風險之間關係的研究進行系統的回顧和薈萃分析。我們的結果是評估咖啡與HCC或肝癌發展的關聯以及預防HCC或肝癌所需的咖啡量。

方法：我們進行了PubMed / MEDLINE / EMBASE / Ovid / Google學術搜索，搜索了1996年至2019年6月以英語發表的原創文章，該研究涉及將咖啡與肝癌或HCC相關的病例對照或隊列研究或前瞻性研究。我們計算了兩種飲用咖啡條件的相對風險（RR），然後將其分層為每天增加一杯咖啡。確定了二十項研究。使用來自DerSimonian和Laird的方法的隨機效應模型進行逆方差加權，進行了分析。計算Cochrane Q和I 2統計量以評估研究之間的異質性。卡方檢驗的p <0.10值和I 2 <20％被認為是低級異質性。使用漏斗圖和Egger檢驗評估發表偏倚的可能性。

結果：研究之間的總體RR為0.69（95％CI 0.56-0.85； p <0.001）。我們對1杯咖啡的增量進行了亞組分析。服用更高劑量的咖啡可大大降低患上HCC或肝癌的風險。漏斗圖未顯示明顯的發布偏差。

結論：我們的系統評價和薈萃分析表明，喝咖啡可以降低HCC或肝癌的風險。就降低風險而言，更高劑量的咖啡具有更高的益處。但是，需要進一步的生物學和流行病學研究來確定確切的機制並研究特定的亞組，例如與病毒性乙型或丙型肝炎相關的肝癌。

StephenW

https://pubmed.ncbi.nlm.nih.gov/32830818/

龙康

我虽然喜欢喝咖啡，但是我觉得喝过量还是不太好的。

独惭康乐

我不喜欢喝咖啡