肝硬化患者常见的焦虑，抑郁

StephenW

Anxiety, depression common among patients with cirrhosis
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Approximately one in six patients with cirrhosis had depression while more than half had moderate-severe anxiety, according to the results of a phone interview survey.

Ruben Hernaez, MD, MPH, PhD, of the section of gastroenterology at Michael E. DeBakey Veterans Affairs Medical Center in Houston, and colleagues wrote that anxiety and depression decrease quality of life and can impact care of chronic diseases dues to missed medical appointments and poor drug adherence.

“Estimates for the prevalence of depression and anxiety are best known in patients with decompensated cirrhosis and liver transplant candidates,” they wrote. “However, the burden of these mental health disorders in a broad cirrhosis patient population, particularly across different health care settings, is lacking.”

Researchers reached out to 2,871 patients with cirrhosis to evaluate the prevalence and risk factors for anxiety and depression. Of the patients they approached for the phone survey, 1,021 patients (35.6%) completed it.

Investigators defined clinically significant depression as a Patient Health Questionairre-9 (PHG9) score of at least 15 and anxiety as a State-Trait Anxiety Inventory (STAI) score of at least 40.

In their study group, Hernaez and colleagues found that the median PHQ9 score was 7, and 15.6% of patients had moderately severe to severe depression. Additionally, they found that the median STAI score was 33, and 42.6% of patients had high anxiety.

Investigators determined that self-reported poor health (OR = 4.08; 95% CI, 1.79-9.28), being widowed (OR = 2.08; 95% CI, 1.07-4.05), fear of hepatocellular carcinoma (OR = 1.89; 95% CI, 1.04-3.42), higher household income (OR = 0.3; 95% CI, 0.1-0.95) and Hispanic ethnicity (OR = 0.57, 95% CI, 0.33-0.97) were all associated with moderately severe to severe depression.

In their analysis they also found that male sex (OR = 0.71; 95% CI, 0.51-0.98), self-reported poor health (OR = 2.73; 95% CI, 1.73-4.32), and fear of hepatocellular carcinoma (OR = 2.24; 95% CI, 1.33-3.78) were associated with high anxiety.

“Even though depression and anxiety are common, with significant implications for patient adherence and satisfaction, these comorbidities unfortunately often go unnoticed in clinical practice,” Hernaez and colleagues wrote. “Screening for depression and anxiety should be encouraged in all patients with cirrhosis to identify those in need of mental health counseling.”

StephenW

肝硬化患者常见的焦虑，抑郁
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根据电话访问调查的结果，大约六分之一的肝硬化患者患有抑郁症，而一半以上的患者患有中度重度焦虑症。

休斯敦迈克尔E.德巴基退伍军人事务医疗中心胃肠病科的鲁本·赫尔内兹（MD），医学博士，博士学位药物依从性差。

他们写道：“对于失代偿性肝硬化和肝移植候选患者，抑郁症和焦虑症的患病率最为人所知。” “但是，缺乏这些精神健康疾病在广大肝硬化患者人群中的负担，尤其是在不同的医疗机构中。”

研究人员接触了2871名肝硬化患者，以评估其焦虑和抑郁的患病率和危险因素。在他们进行电话调查的患者中，有1,021位患者（35.6％）完成了电话调查。

研究人员将临床上显着的抑郁症定义为患者健康Questionairre-9（PHG9）得分至少为15，而焦虑症的状态特质焦虑量表（STAI）得分至少为40。

Hernaez及其同事在他们的研究组中发现，PHQ9的中位数为7，有15.6％的患者患有中度重度至重度抑郁。此外，他们发现中位STAI评分为33，有42.6％的患者患有高焦虑症。

研究者确定自我报告的健康状况不佳（OR = 4.08; 95％CI，1.79-9.28），被遗（（OR = 2.08; 95％CI，1.07-4.05），害怕肝细胞癌（OR = 1.89; 95％CI （1.04-3.42），较高的家庭收入（OR = 0.3； 95％CI，0.1-0.95）和西班牙裔种族（OR = 0.57，95％CI，0.33-0.97）均与中度重度到重度抑郁症相关。

在他们的分析中，他们还发现男性（OR = 0.71； 95％CI，0.51-0.98），自我报告的健康状况不佳（OR = 2.73； 95％CI，1.73-4.32）和对肝细胞癌的恐惧（OR = 2.24; 95％CI，1.33-3.78）与高焦虑症相关。

“尽管抑郁症和焦虑症很普遍，对患者的依从性和满意度都有重大影响，但不幸的是，这些合并症在临床实践中常常没有被注意到，” Hernaez和同事写道。 “应鼓励所有肝硬化患者进行抑郁和焦虑筛查，以找出需要心理健康咨询的人。”

怀念母亲

我也抑郁

lqman

社会压力本来就大, 再加疫情,和病情...

nana2ferrari

lqman 发表于 2020-8-26 19:23
社会压力本来就大, 再加疫情,和病情...

是的，说的太对了

柏舟

花有重开日、人无再少年。
好好珍惜这几十年，转瞬就过去，

吃药啥时停

身体有诸多不适，不停地花钱，难免焦虑。