乙型肝炎表面抗原水平低的慢性乙型肝炎患者的臨床特徵和

StephenW

Clinical features of chronic hepatitis B patients with low hepatitis B surface antigen levels and determinants of hepatitis B surface antigen seroclearance
Hideaki Taniguchi  1 , Yoshiaki Iwasaki  2 , Masahito Aimi  1 , Gaku Shimazaki  1 , Akio Moriya  3
Affiliations
Affiliations

    1
    Internal Medicine Tottori Municipal Hospital Tottori Japan.
    2
    Health Service Center Okayama University Okayama Japan.
    3
    Gastroenterology Mitoyo General Hospital Japan.

    PMID: 32782959 PMCID: PMC7411555 DOI: 10.1002/jgh3.12321

Abstract

Background and aim: A low hepatitis B surface antigen (HBsAg) level is reported to be predictive of future HBsAg seroclearance. A hospital-based cohort study was conducted to clarify the clinical features of patients with low HBsAg levels and to demonstrate the usefulness of low HBsAg levels for predicting HBsAg seroclearance.

Methods: A total of 1459 patients with chronic hepatitis B were included in the study. Of these, 587 had repeated measurements for HBsAg levels and two or more records of HBsAg-positive results. HBsAg levels were measured with a commercially available HBsAg assay. Based on a cut-off index (COI) of 2000, a high HBsAg level was defined as HBsAg ≥2000 COI, and a low HBsAg level was defined as HBsAg <2000 COI.

Results: The proportion of patients with low HBsAg levels at baseline tended to increase with age. Patients with low HBsAg levels at baseline had significantly older age, lower transaminase levels, and lower hepatitis B virus (HBV) DNA levels than those with high HBsAg levels. The annual HBsAg seroclearance rate was 1.30%/year. The cumulative incidences of HBsAg seroclearance differed significantly by HBsAg level at baseline (<2000 vs ≥2000 COI), age (≥50 vs <50 years), and HBV DNA level (<4.0 vs ≥4.0 log copies/mL). Cox proportional hazards regression analyses showed that low HBsAg level (<2000 COI) and low HBV DNA level (<4.0 log copies/mL) were significantly associated with HBsAg seroclearance.

Conclusion: Aging was one of the factors affecting HBsAg level. HBsAg seroclearance was significantly associated with low HBsAg level and low HBV DNA level at baseline.

Keywords: aging; hepatitis B surface antigen; hepatitis B surface antigen seroclearance; hepatitis B virus DNA.

© 2020 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

StephenW

乙型肝炎表面抗原水平低的慢性乙型肝炎患者的臨床特徵和乙型肝炎表面抗原血清清除的決定因素
谷口秀明1，岩崎佳明2，雅人正人1，島崎學1，森谷明3
隸屬關係
隸屬關係

    1個
    日本鳥取市鳥取市立醫院內科。
    2
    日本岡山大學保健服務中心。
    3
    日本三豐綜合醫院消化內科。

    PMID：32782959 PMCID：PMC7411555 DOI：10.1002 / jgh3.12321

抽象

背景與目的：據報導乙肝表面抗原（HBsAg）水平低可預示未來HBsAg血清清除。進行了一項基於醫院的隊列研究，以闡明HBsAg水平低的患者的臨床特徵，並證明HBsAg水平低對預測HBsAg血清清除的有用性。

方法：共納入1459例慢性乙型肝炎患者。其中，有587例重複測量了HBsAg水平，並記錄了兩個或多個HBsAg陽性結果。 HBsAg水平用市售的HBsAg測定法測量。根據2000年的臨界指數（COI），將高HBsAg水平定義為HBsAg≥2000 COI，將低HBsAg水平定義為HBsAg <2000 COI。

結果：基線時HBsAg水平低的患者比例隨年齡增長而增加。與高HBsAg水平的患者相比，基線時HBsAg水平低的患者俱有明顯更高的年齡，較低的轉氨酶水平和較低的乙肝病毒（HBV）DNA水平。年度HBsAg血清清除率為1.30％/年。 HBsAg血清清除的累積發生率在基線（<2000 vs≥2000 COI），年齡（≥50vs <50歲）和HBV DNA水平（<4.0 vs≥4.0log copy / mL）之間存在顯著差異。 Cox比例風險回歸分析表明，低HBsAg水平（<2000 COI）和低HBV DNA水平（<4.0 log copy / mL）與HBsAg血清清除率顯著相關。

結論：衰老是影響HBsAg水平的因素之一。基線時，HBsAg血清清除率與HBsAg低水平和HBV DNA低水平顯著相關。

關鍵詞：老化乙型肝炎表面抗原；乙肝表面抗原血清清除；乙肝病毒DNA。

©2020作者。 JGH Open：《胃腸病和肝病學雜誌》和John Wiley＆Sons Australia，Ltd.出版的《胃腸病學和肝病學》開放期刊。

StephenW

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jgh3.12321