循环microRNA在低甲胎蛋白水平的乙型肝炎病毒相关肝细胞癌诊

StephenW

The role of circulating microRNAs for the diagnosis of hepatitis B virus-associated hepatocellular carcinoma with low alpha-fetoprotein level: a systematic review and meta-analysis
Cheng Peng  1   2 , Zhuonan Li  3 , Zishan Xie  1   4 , Zhanpeng Wang  1 , Yanshuo Ye  1 , Bo Li  5 , Wei Li  6
Affiliations
Affiliations

    1
    Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, China.
    2
    Department of Hepatobiliary-Pancreatic Surgery, Third Xiangya Hospital of Central South University, Changsha, 410013, China.
    3
    Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
    4
    Department of Ultrasonography, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518020, China.
    5
    Department of Epidemiology, School of Public Health of Jilin University, Changchun, 130021, China.
    6
    Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, 130033, China. [email protected].

    PMID: 32736604 DOI: 10.1186/s12876-020-01345-5

Abstract

Background: Alpha-fetoprotein (AFP) has been widely used for many years as a serum marker for hepatocellular carcinoma (HCC). However, AFP has been recognized as having poor sensitivity. More and more studies have concluded that circulating microRNAs (miRNAs) might be a promising biomarker that could complement AFP. However, the diagnostic ability of circulating miRNAs has varied among the studies. Therefore, we performed the present meta-analysis to appraise the diagnostic performance of circulating miRNAs as a biomarker for hepatitis B virus-associated HCC (HBV-HCC) patients with low AFP levels.

Methods: We performed a systematic review and meta-analysis of the published literature to assess the diagnostic accuracy of circulating miRNAs in differentiating HBV-HCC patients with low AFP levels from non-HCC controls.

Results: Circulating miRNAs showed promising potential in the diagnosis of HBV-HCC patients with low AFP levels. In the low-AFP HBV-HCC patients, the area under the curve (AUC) was 0.88 (95% confidence interval [CI]: 0.84-0.90). The pooled sensitivity and specificity were 0.84 (95% CI: 0.78-0.88) and 0.76 (95% CI: 0.69-0.83), respectively.

Conclusions: The detection of circulating miRNAs provides a valuable method for the diagnosis of HBV-HCC in patients with low AFP levels.

Keywords: Diagnosis; HCC; Low AFP; Meta-analysis; miRNAs.

StephenW

循环microRNA在低甲胎蛋白水平的乙型肝炎病毒相关肝细胞癌诊断中的作用：系统评价和荟萃分析
程鹏1 2，卓南李3，紫山谢1 4，王占鹏1，严硕烨1，伯丽5，魏丽6
隶属关系
隶属关系

    1个
    吉林大学中日联合医院肝胆胰外科，吉林长春仙台街126号，吉林130033
    2
    中南大学湘雅三医院肝胆胰外科，长沙410013
    3
    吉林大学中日联合医院整形外科，吉林长春130033
    4
    中山大学附属第八医院超声科，深圳518020
    5
    吉林大学公共卫生学院流行病学教研室，吉林长春130021
    6
    吉林大学中日联合医院肝胆胰外科，吉林长春仙台街126号，吉林130033 [email protected]。

    PMID：32736604 DOI：10.1186 / s12876-020-01345-5

抽象

背景：甲胎蛋白（AFP）已被广泛用作肝细胞癌（HCC）的血清标志物。但是，AFP被认为灵敏度低。越来越多的研究得出结论，循环微RNA（miRNA）可能是一种有前途的生物标志物，可以补充AFP。但是，在研究中，循环miRNA的诊断能力有所不同。因此，我们进行了本荟萃分析，以评估循环miRNA作为低AFP水平的乙肝病毒相关HCC（HBV-HCC）患者的生物标志物的诊断性能。

方法：我们对已发表的文献进行了系统的回顾和荟萃分析，以评估循环miRNA在区分AFP水平低的HBV-HCC患者和非HCC对照中的诊断准确性。

结果：循环中的miRNA在诊断AFP水平低的HBV-HCC患者中显示出有希望的潜力。在低AFP HBV-HCC患者中，曲线下面积（AUC）为0.88（95％置信区间[CI]：0.84-0.90）。合并的敏感性和特异性分别为0.84（95％CI：0.78-0.88）和0.76（95％CI：0.69-0.83）。

结论：循环miRNA的检测为AFP水平低的患者诊断HBV-HCC提供了有价值的方法。

关键字：诊断； HCC； AFP低；荟萃分析； miRNA。