初治HBeAg阴性的HBV感染成年患者的病毒学活动：基于江苏省的

StephenW

Virological activity in treatment-naïve HBeAg-negative HBV-infected adult patients: A community-based study in Jiangsu, China
Xiangjun Zhai  1 , Liguo Zhu, Jie Jiang, Ci Song, Hong Peng, Jiao Qian, MingHao Zhou, Yan Zhou, Qungang Wang, Jianfang Xu, Zhijian Wang, Hongjian Liu, Min Fan, Zhibin Hu, Hongbin Shen, Fengcai Zhu
Affiliations

    PMID: 32702877 DOI: 10.1097/MD.0000000000021179

Abstract

Nowadays most of the hepatitis B virus (HBV) infected population are adults, among which hepatitis B e antigen (HBeAg) negative infection occupied the largest proportion of HBV infection in China. HBeAg-negative patients are heterogeneous, and the corresponding interventions are different. Therefore, it is worth researching the infection characteristics of HBeAg-negative patients to help guide the interventions.A total of 11,738 treatment-naïve HBeAg-negative adult patients were randomly selected, and their demographic and medical history information were collected. The liver biochemistry, and HBV infection biomarkers including hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), HBeAg, hepatitis B e antibody (anti-HBe), hepatitis B core antibody (anti-HBc), and hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels were tested. The infection characteristics and their influencing factors were explored.Sixty percent of the patients presented HBV-DNA-positive, of which 31.2% had HBV-DNA level higher than 2000 IU/mL, and 16.5% had HBV-DNA level higher than 20,000 IU/mL. HBV-DNA levels tended to increase along with the increasing of age, and the male patients had significant higher HBV-DNA levels than the female patients. Twenty-four percent of the patients had abnormal transaminase. The male patients were more vulnerable to abnormal transaminase (30.0%) than the female patients (18.4%). Fifty-five percent patients with HBV-DNA ≥20,000 IU/mL presented abnormal alanine aminotransferase (ALT) or aspartate transaminase (AST), which was significantly higher than that of patients with HBV-DNA levels below 20,000 IU/mL (19.0-21.7%). Multivariate logistic regression analyses revealed that the male patients and the patients with higher viral load had higher risk of having abnormal liver function.A considerable number of HBeAg-negative patients were virological active and had liver damage. It is necessary and urgent to carry out regular active interventions for the chronic HBV-infected patients.
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StephenW

初治HBeAg阴性的HBV感染成年患者的病毒学活动：基于江苏省的社区研究
翟向军1，朱丽果，姜杰，词曲，洪鹏，焦干，周明豪，周燕，王群刚，徐建芳，王志坚，刘建建，范范，胡志斌，沉洪斌，朱凤才
隶属关系

    PMID：32702877 DOI：10.1097 / MD.0000000000021179

抽象

如今，大多数乙型肝炎病毒感染人群都是成年人，其中乙型肝炎e抗原（HBeAg）阴性感染在中国占最大比例。 HBeAg阴性患者是异质性的，相应的干预措施也不同。因此，有必要研究HBeAg阴性患者的感染特征以帮助指导干预措施。随机选择11738名未接受过治疗的HBeAg阴性成人患者，并收集其人口统计学和病史信息。肝脏生物化学和HBV感染生物标志物，包括乙肝表面抗原（HBsAg），乙肝表面抗体（抗HBs），HBeAg，乙肝e抗体（抗HBe），乙肝核心抗体（抗HBc）和测试了乙型肝炎病毒脱氧核糖核酸（HBV-DNA）的水平。探讨了感染的特点及其影响因素。60％的患者HBV-DNA阳性，其中HBV-DNA水平高于2000 IU / mL的占31.2％，HBV-DNA水平高于20000 IU的占16.5％。 /毫升HBV-DNA水平倾向于随着年龄的增长而增加，男性患者的HBV-DNA水平明显高于女性患者。 24％的患者转氨酶异常。男性患者（30.0％）比女性患者（18.4％）更容易受到转氨酶异常的影响。 55％的HBV-DNA≥20,000 IU / mL的患者出现异常的丙氨酸氨基转移酶（ALT）或天冬氨酸转氨酶（AST），这明显高于HBV-DNA低于20,000 IU / mL的患者（19.0-21.7 ％）。多元logistic回归分析显示，男性患者和病毒载量较高的患者肝功能异常的风险更高。相当多的HBeAg阴性患者具有病毒学活性并具有肝损害。对慢性乙型肝炎病毒感染的患者进行定期主动干预是必要和紧迫的。

StephenW

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