HBsAg水平低的HBeAg阴性患者肝组织病理变化及相关因素分析

StephenW

Analysis of pathological changes and related factors in liver tissue of HBeAg-negative patients with low HBsAg levels
Li Liu  1 , Chunyun Liu  2 , Junyi Li  2 , Yingrong Du  2 , Jie Chen  2 , Hui Wang  2 , Huimin Li  2 , Lixian Chang  2
Affiliations
Affiliations

    1
    Department of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China. [email protected].
    2
    Department of Liver Disease, The Third People's Hospital of Kunming City, No. 319, Wujing Road, Guandu District, Kunming, 650011, Yunnan, China.

    PMID: 32656675 DOI: 10.1007/s10238-020-00645-0

Abstract

The relationship between pathological changes in liver tissue and the level of hepatitis B surface antigen (HBsAg) remains unclear. This study aimed to analyze the pathological changes in liver tissue and its related factors in patients with low-level HBsAg in order to provide a basis for judging the condition of these patients. A retrospective study was performed on 96 chronic hepatitis B patients with HBsAg levels < 1400 IU/ml and > 0.05 IU/ml. The histopathological examination of these patients was conducted. Univariate and multivariate analyses were used to determine risk factors for pathological changes. Among the 96 patients, 57.3% (55) had inflammatory events ≥ G2 and 33.4% (33) had fibrosis ≥ S2. HBV infection duration (p = 0.001) and splenic vein diameter (p = 0.001) were independent risk factors of liver inflammation (≥ G2) in patients with low-level HBsAg, while AST (p = 0.006) and PLT (p = 0.005) were independent risk factors of liver fibrosis (≥ S2). Moreover, HBV infection duration (p < 0.001) and spleen vein (p = 0.001) were independent factors of potential antiviral treatment. Liver inflammation and fibrosis are still common in patients with low-level HBsAg; thus, the monitoring and appropriate antiviral treatment cannot be ignored.

Keywords: Fibrosis staging; Inflammation grade; Liver histopathology; Low levels of HBsAg; Related factors.

StephenW

HBsAg水平低的HBeAg阴性患者肝组织病理变化及相关因素分析
刘力1，刘春云2，李俊一2，杜颖荣2，陈杰2，慧王2，李慧敏2，李先昌2
隶属关系
隶属关系

    1个
    昆明市关渡区武井路319号昆明市第三人民医院肝病科，云南650011 [email protected]。
    2
    昆明市关渡区武井路319号昆明市第三人民医院肝病科，云南650011

    PMID：32656675 DOI：10.1007 / s10238-020-00645-0

抽象

肝组织病理变化与乙型肝炎表面抗原（HBsAg）水平之间的关系尚不清楚。本研究旨在分析低水平HBsAg患者肝组织的病理变化及其相关因素，为判断这些患者的病情提供依据。对96例HBsAg水平<1400 IU / ml和> 0.05 IU / ml的慢性乙型肝炎患者进行了回顾性研究。对这些患者进行了组织病理学检查。单因素和多因素分析用于确定病理变化的危险因素。在96名患者中，有57.3％（55）的炎症事件≥G2，有33.4％（33）的纤维化≥S2。低水平HBsAg患者的HBV感染持续时间（p = 0.001）和脾静脉直径（p = 0.001）是肝脏炎症（≥G2）的独立危险因素，而AST（p = 0.006）和PLT（p = 0.005）是肝纤维化的独立危险因素（≥S2）。此外，HBV感染持续时间（p <0.001）和脾静脉（p = 0.001）是潜在抗病毒治疗的独立因素。低水平HBsAg患者肝炎和纤维化仍很常见。因此，监测和适当的抗病毒治疗不可忽视。

关键词：纤维化分期