用于肝细胞癌早期发现的循环生物标志物

StephenW

Circulating Biomarkers for Early Detection of Hepatocellular Carcinoma
Boris J B Beudeker  1 , Andre Boonstra  2
Affiliations
Affiliations

    1
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
    2
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Wytemaweg 80, Rotterdam, 3015 CE, the Netherlands.

    PMID: 32647536 PMCID: PMC7325534 DOI: 10.1177/1756284820931734

Abstract

Hepatocellular carcinoma (HCC) is estimated to be the fourth leading cause of cancer-related deaths worldwide. HCC patients face a dismal prognosis because symptoms usually appear in an advanced stage of disease. The detection of early stage HCC allows for curative surgical treatment and therefore saves lives. Specific non-invasive or diagnostic markers for HCC may represent a valuable tool for detecting these tumors at an early stage. The clinically most established serological biomarker alpha-fetoprotein shows only limited diagnostic performance, however novel candidate biomarkers and biomarker panels for detecting HCC at early stages of development are being studied. In this review we will discuss the findings of these studies.

Keywords: diagnostics; early biomarkers; early diagnosis; hepatitis B virus; hepatitis C virus; hepatocellular carcinoma; immunology; liquid biopsy; micro RNA; surveillance; viral hepatitis.

© The Author(s), 2020.

StephenW

用于肝细胞癌早期发现的循环生物标志物
Boris J B Beudeker 1和Andre Boonstra 2
隶属关系
隶属关系

    1个
    荷兰鹿特丹大学医学中心，伊拉斯姆斯大学胃肠病和肝病学系。
    2
    鹿特丹大学医学中心伊拉斯姆斯大学消化内科和肝病科，公元3015年，荷兰鹿特丹Wytemaweg 80。

    PMID：32647536 PMCID：PMC7325534 DOI：10.1177 / 1756284820931734

抽象

据估计，肝细胞癌（HCC）是全球癌症相关死亡的第四大主要原因。 HCC患者面临不良的预后，因为症状通常出现在疾病的晚期。早期HCC的检测可以治愈性手术，从而挽救生命。 HCC的特定非侵入性或诊断性标志物可能代表了早期检测这些肿瘤的有价值的工具。临床上最建立的血清生物标志物甲胎蛋白仅显示有限的诊断性能，但是正在研究在发展的早期阶段检测HCC的新型候选生物标志物和生物标志物组。在这篇综述中，我们将讨论这些研究的结果。

关键字：诊断；早期生物标志物；早期诊断；乙型肝炎病毒;丙型肝炎病毒；肝细胞癌；免疫学液体活检微小RNA；监视病毒性肝炎。

©作者，2020年。

StephenW

https://journals.sagepub.com/doi/pdf/10.1177/1756284820931734