使用肝活检作为金标准，使用声辐射力脉冲成像技术与瞬时

StephenW

Virtual Touch Quantification Using Acoustic Radiation Force Impulse Imaging Technology Versus Transient Elastography for the Noninvasive Assessment of Liver Fibrosis in Patients With Chronic Hepatitis B or C Using Liver Biopsy as the Gold Standard
Victor Bâldea  1 , Ioan Sporea  2 , Anca Tudor  3 , Alina Popescu  4 , Felix Bende  5 , Roxana Șirli  6
Affiliations
Affiliations

    1
    Department of Gastroenterology and Hepatology, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania. . [email protected].
    2
    Department of Gastroenterology and Hepatology, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania. [email protected].
    3
    Department of Informatics and Medical Biostatistics, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania. [email protected].
    4
    Department of Gastroenterology and Hepatology, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania. [email protected].
    5
    Department of Gastroenterology and Hepatology, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania. [email protected].
    6
    Department of Gastroenterology and Hepatology, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania. [email protected].

    PMID: 32530985 DOI: 10.15403/jgld-2256

Abstract

Aims: Our aim was to assess the diagnostic performance of transient elastography (TE) and Virtual Touch Quantification (VTQ), a point Shear Wave Elastography (pSWE) technique, using Acoustic Radiation Force Impulse (ARFI) technology, for liver fibrosis assessment, as compared to percutaneous liver biopsy (LB), in patients with chronic hepatitis B or C.

Methods: We analyzed 157 patients (80 with chronic hepatitis B and 77 with chronic hepatitis C) with reliable liver stiffness (LS) measurements, in whom we compared TE and VTQ to the LB performed during the same session (evaluated according to the Metavir scoring system: F0-F4). LS was assessed by TE (FibroScan, EchoSens, Paris, France) and VTQ using the Siemens Acuson S2000TM ultrasound system (Siemens AG, Erlangen, Germany). We defined reliable LS measurements as the median value of 10 measurements with an IQR/M <30% for both TE (obtained using the M probe) and VTQ. The areas under receiver operating characteristic curves (AUROCs) were used to assess the diagnostic performance of TE and VTQ. Correlation analysis determined the relationship between LSM values and liver histology.

Results: On LB 31 (19.7%) patients had no fibrosis, 35 (22.3%) had F1, 43 (27.4%) had F2, 28 (17.8%) had F3 and 20 (12.7%) had cirrhosis. The mean size of the liver specimen in LB was 27 mm. A strong, linear correlation (Spearman ρ=0.826; p<0.001) with 95% confidence interval for rho (0.769- 0.870), was found between the TE and VTQ measurements. By comparing the AUROC curves, TE and VTQ had similar predictive values for the presence of F≥1 Metavir: AUROC TE=0.876, AUROC VTQ=0.832, p=0.358, for F≥2 Metavir: AUROC TE=0.826, AUROC VTQ=0.862, p=0.313, for F≥3 Metavir: AUROC TE=0.907, AUROC VTQ=0.880, p=0.434 and for F=4 Metavir: AUROC TE=0.981, AUROC VTQ=0.974, p= 0.423.

Conclusions: Both methods, TE and VTQ (pSWE) offer excellent diagnostic accuracy for liver fibrosis assessment in patients with chronic hepatitis B or C with similar performance.

Search result 1 of 99,310 for hepatitis b

StephenW

使用肝活检作为金标准，使用声辐射力脉冲成像技术与瞬时弹性成像技术进行的虚拟触摸定量与瞬时弹性成像技术的比较，用于无创性评估慢性乙型或丙型肝炎患者肝纤维化
VictorBâldea1，Ioan Sporea 2，Anca Tudor 3，Alina Popescu 4，Felix Bende 5，Roxana Șirli 6
隶属关系
隶属关系

    1个
    Victor Babeș医药大学，胃肠病学和肝病学系，罗马尼亚蒂米什瓦拉。 。 [email protected]。
    2
    Victor Babeș医药大学，胃肠病学和肝病学系，罗马尼亚蒂米什瓦拉。 [email protected]。
    3
    Victor Babeș医药大学，信息学和医学生物统计学系，罗马尼亚蒂米什瓦拉。 [email protected]。
    4
    Victor Babeș医药大学，胃肠病学和肝病学系，罗马尼亚蒂米什瓦拉。 [email protected]。
    5
    Victor Babeș医药大学，胃肠病学和肝病学系，罗马尼亚蒂米什瓦拉。 [email protected]。
    6
    Victor Babeș医药大学，胃肠病学和肝病学系，罗马尼亚蒂米什瓦拉。 [email protected]。

    PMID：32530985 DOI：10.15403 / jgld-2256

抽象

目的：我们的目的是使用声辐射力脉冲（ARFI）技术评估瞬时弹性成像（TE）和虚拟触摸定量（VTQ）（一种点剪切波弹性成像（pSWE）技术）的诊断性能，以评估肝纤维化，与经皮肝活检（LB）相比，慢性乙型或丙型肝炎患者

方法：我们分析了157例患者（其中80例慢性乙型肝炎和77例慢性丙型肝炎）具有可靠的肝劲度（LS）测量，我们将TE和VTQ与同一疗程中进行的LB进行了比较（根据Metavir评分进行评估）系统：F0-F4）。 LS是由TE（FibroScan，EchoSens，法国巴黎）和VTQ使用Siemens Acuson S2000TM超声系统（Siemens AG，​​德国埃尔兰根）评估的。我们将可靠的LS测量定义为TE（使用M探针获得）和VTQ的IQR / M <30％的10次测量的中值。接收器工作特性曲线（AUROC）下的面积用于评估TE和VTQ的诊断性能。相关分析确定了LSM值与肝脏组织学之间的关系。

结果：在LB组中，无纤维化的31例（19.7％），F1的35例（22.3％），F2的43例（27.4％），F3的28例（17.8％）和肝硬化的20例（12.7％）。 LB中肝脏标本的平均大小为27毫米。在TE和VTQ测量之间发现具有95％置信区间rho（0.769-0.870）的强线性相关（Spearmanρ= 0.826； p <0.001）。通过比较AUROC曲线，TE和VTQ对于F≥1Metavir的存在具有相似的预测值：AUROC TE = 0.876，AUROC VTQ = 0.832，p = 0.358，对于F≥2Metavir：AUROC TE = 0.826，AUROC VTQ =对于F≥3 Metavir：AUROC TE = 0.907，AUROC VTQ = 0.880，p = 0.434，p = 0.313，对于F = 4 Metavir：AUROC TE = 0.981，AUROC VTQ = 0.974，p = 0.423，p = 0.313。

结论：TE和VTQ（pSWE）这两种方法对于性能相似的慢性B或C型肝炎患者的肝纤维化评估均具有出色的诊断准确性。