丁型肝炎感染：从最初的发现到当前的研究治疗

StephenW

Hepatitis D Infection: From Initial Discovery to Current Investigational Therapies
Ben L Da  1 , Theo Heller  2 , Christopher Koh  2
Affiliations
Affiliations

    1
    Digestive Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
    2
    Liver Diseases Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

    PMID: 32477569 PMCID: PMC6691517 DOI: 10.1093/gastro/goz023

Abstract

Hepatitis D is the most severe form of viral hepatitis associated with a more rapid progression to cirrhosis and an increased risk of hepatocellular carcinoma and mortality compared with hepatitis B mono-infection. Although once thought of as a disappearing disease, hepatitis D is now becoming recognized as a serious worldwide issue due to improvement in diagnostic testing and immigration from endemic countries. Despite these concerns, there is currently only one accepted medical therapy (pegylated-interferon-α) for the treatment of hepatitis D with less than desirable efficacy and significant side effects. Due to these reasons, many patients never undergo treatment. However, increasing knowledge about the virus and its life cycle has led to the clinical development of multiple promising new therapies that hope to alter the natural history of this disease and improve patient outcome. In this article, we will review the literature from discovery to the current investigational therapies.

Keywords: Hepatitis D; epidemiology; hepatitis B; natural history; novel therapies; outcome; treatment.

Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University.

StephenW

丁型肝炎感染：从最初的发现到当前的研究治疗
Ben L Da 1，Theo Heller 2，Christopher Koh 2
隶属关系
隶属关系

    1个
    美国马里兰州贝塞斯达市国立卫生研究院糖尿病与消化与肾脏疾病研究所，消化疾病科。
    2
    美国马里兰州贝塞斯达市国立卫生研究院国立糖尿病，消化与肾脏疾病研究所肝病科。

    PMID：32477569 PMCID：PMC6691517 DOI：10.1093 / gastro / goz023

抽象

与乙型肝炎单一感染相比，丁型肝炎是最严重的病毒性肝炎形式，与肝硬化进展更快，肝细胞癌风险和死亡率增加有关。尽管曾经被认为是一种正在消失的疾病，但由于诊断测试的改进和来自流行国家的移民，D型肝炎现在已被认为是一个严重的全球性问题。尽管存在这些担忧，但目前仅有一种公认的药物疗法（聚乙二醇化干扰素-α）用于治疗D型肝炎，但疗效不理想，且副作用明显。由于这些原因，许多患者从未接受过治疗。但是，对病毒及其生命周期的了解不断增加，导致了多种有前途的新疗法的临床开发，这些新疗法有望改变这种疾病的自然病史并改善患者预后。在本文中，我们将回顾从发现到当前研究疗法的文献。

关键字：丁型肝炎；流行病学乙型肝炎；自然历史;新疗法；结果;治疗。

由牛津大学出版社和中山大学附属第六医院出版。

StephenW

https://academic.oup.com/gastro/ ... 29114830/goz023.pdf