乙肝病毒感染和中国人群患癌症的风险

StephenW

Hepatitis B Virus Infection and the Risk of Cancer Among the Chinese Population
Ting Tian  1   2 , Ci Song  1   2   3 , Longfeng Jiang  4 , Jingjing Dai  4 , Yuan Lin  1   2 , Xin Xu  1   2 , Chengxiao Yu  1   2 , Zijun Ge  5 , Yuqing Ding  1   2 , Yang Wen  1   2 , Bo Liu  4 , Yuyun Shao  4 , Ping Shi  4 , Chuanlong Zhu  4 , Yuan Liu  4 , Shenqi Jing  6 , Zhongmin Wang  6 , Zhibin Hu  1   2 , Jun Li  4
Affiliations
Affiliations

    1
    Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
    2
    Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.
    3
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, China.
    4
    Department of Infectious Disease, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China.
    5
    Office of Infection Management, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China.
    6
    Information Department, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China.

    PMID: 32478856 DOI: 10.1002/ijc.33130

Abstract

The relationship between hepatitis B virus (HBV) and non-hepatocellular cancers remains inconclusive. This large case-control study aimed to assess the associations between HBV infection status and multiple cancers. Cases (N = 50 392) and controls (N = 11 361) were consecutively recruited from 2008 to 2016 at the First Affiliated Hospital of Nanjing Medical University. Multivariable adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression by adjusting age and gender. A meta-analysis based on published studies was also performed to verify the associations. 12.1% of cases and 5.5% of controls were hepatitis B surface antigen (HBsAg) seropositive. We observed significant associations between HBsAg seropositivity and oesophagus cancer (aOR[95%CI] = 1.32[1.13-1.54]), stomach cancer (1.46[1.30-1.65]), hepatocellular carcinoma (HCC) (39.11[35.08-43.59]), intrahepatic and extrahepatic bile duct carcinoma (ICC and ECC) (3.83[2.58-5.67] and 1.72[1.28-2.31]), pancreatic cancer (PaC) (1.37[1.13-1.65]), non-Hodgkin lymphoma (NHL) (1.88[1.61-2.20]) and leukaemia (11.48[4.05-32.56]). Additionally, compared with participants with HBsAg-/anti-HBs-/anti-HBc-, participants with HBsAg-/anti-HBs-/anti-HBc+, indicating past HBV-infected, had an increased risk of oesophagus cancer (aOR[95%CI] = 1.46[1.24-1.73]), stomach cancer (1.20[1.04-1.39]), HCC (4.80[3.95-5.84]) and leukeamia (15.62[2.05-119.17]). Then the overall meta-analysis also verified that HBsAg seropositivity was significantly associated with stomach cancer (OR[95%CI] = 1.23[1.14-1.35]), ICC (4.05[2.78-5.90]), ECC (1.73[1.30-2.30]), PaC (1.26[1.09-1.46]), NHL (1.95[1.55-2.44]) and leukaemia (1.54[1.26-1.88]). In conclusion, both our case-control study and meta-analysis confirmed the significant association of HBsAg seropositivity with stomach cancer, ICC, ECC, PaC, NHL and leukaemia. Of note, our findings also suggested that the risk of stomach cancer elevated for people who ever exposed to HBV.

Keywords: Hepatitis B virus; cancer; case-control study; meta-analysis.

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StephenW

乙肝病毒感染和中国人群患癌症的风险
婷婷1 2，词曲1 2 3，姜龙凤4，景晶黛4，袁琳1 2，新旭1 2，成晓瑜1 2，紫君阁5，丁玉卿1 2，杨雯1 2，刘波4，邵宇云4，平石4，朱传龙4，刘元4，神起经6，王中敏6，胡志斌1 2，君利4
隶属关系
隶属关系

    1个
    南京医科大学公共卫生学院全球卫生中心流行病学教研室，南京
    2
    南京医科大学肿瘤医学协同创新中心，江苏省肿瘤生物标志物，预防与治疗重点实验室，南京
    3
    南京医科大学微生物与免疫学系，南京
    4
    江苏省医院和南京医科大学附属第一医院传染病科，南京。
    5
    江苏省医院和南京医科大学附属第一医院感染管理办公室，南京。
    6
    江苏省医院和南京医科大学第一附属医院信息部，南京。

    PMID：32478856 DOI：10.1002 / ijc.33130

抽象

乙肝病毒（HBV）与非肝细胞癌之间的关系尚无定论。这项大型病例对照研究旨在评估HBV感染状况与多种癌症之间的关联。从2008年至2016年，在南京医科大学第一附属医院连续招募病例（N = 50 392）和对照组（N = 11 361）。使用逻辑回归通过调整年龄和性别来估计多变量调整后的优势比（aOR）和95％置信区间（95％CI）。还进行了基于已发表研究的荟萃分析以验证关联。乙型肝炎表面抗原（HBsAg）血清阳性的病例为12.1％，对照组为5.5％。我们观察到HBsAg血清阳性与食道癌（aOR [95％CI] = 1.32 [1.13-1.54]），胃癌（1.46 [1.30-1.65]），肝细胞癌（HCC）（39.11 [35.08-43.59]）之间存在显着关联。 ，肝内和肝外胆管癌（ICC和ECC）（3.83 [2.58-5.67]和1.72 [1.28-2.31]），胰腺癌（PaC）（1.37 [1.13-1.65]），非霍奇金淋巴瘤（NHL）（ 1.88 [1.61-2.20]）和白血病（11.48 [4.05-32.56]）。此外，与接受HBsAg //抗-HBs- /抗-HBc-的参与者相比，接受过HBsAg //抗-HBs- /抗-HBc +的参与者表明曾经感染过HBV，食管癌的风险增加（aOR [95 ％CI] = 1.46 [1.24-1.73]），胃癌（1.20 [1.04-1.39]），HCC（4.80 [3.95-5.84]）和白血病（15.62 [2.05-119.17]）。然后，整体荟萃分析还证实HBsAg血清阳性与胃癌（OR [95％CI] = 1.23 [1.14-1.35]），ICC（4.05 [2.78-5.90]），ECC（1.73 [1.30-2.30]显着相关。 ]），PaC（1.26 [1.09-1.46]），NHL（1.95 [1.55-2.44]）和白血病（1.54 [1.26-1.88]）。总之，我们的病例对照研究和荟萃分析均证实HBsAg血清阳性与胃癌，ICC，ECC，PaC，NHL和白血病之间存在显着相关性。值得注意的是，我们的发现还表明，曾经接触过HBV的人患胃癌的风险升高。

关键词：乙型肝炎病毒；癌症;病例对照研究；荟萃分析。

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