在美国患有慢性乙型肝炎的成年人中的死亡率：一项基于人

StephenW

Mortality in adults with chronic hepatitis B infection in the United States: A population‐based study
Zhou K, Dodge JL, Grab J
Alimentary Pharmacology and Therapeutics
|
May 23, 2020

Since chronic hepatitis B infection represents a crucial contributor to mortality in the US, researchers analyzed National Health and Nutrition Examination Surveys participants between 1999 and 2014 linked to National Death Index data, to compare those with chronic, prior and no hepatitis B infection, in terms of risks as well as predictors of mortality in a recent time period. This study included adults aged 20 years or older with hepatitis B serologic testing, who were 39,206 in total, including 192 (0.5%) with chronic and 2,694 (6.9%) with prior hepatitis B infection. Heavy alcohol use and higher alanine aminotransferase were identified as the factors that predicted all‐cause mortality among chronic infection. Overall, it was revealed that even the availability of improved therapeutics could not prevent a higher mortality to be experienced by adults living with chronic hepatitis B infection vs mortality observed in uninfected adults. Improved survival can be ensured via detection of chronic infection, start of treatment among eligible and modulation of co‐factors for disease advancement.

Read the full article on Alimentary Pharmacology and Therapeutics.

StephenW

在美国患有慢性乙型肝炎的成年人中的死亡率：一项基于人群的研究
周K，道奇JL，Grab J
消化药理学和治疗学
|
2020年5月23日

由于慢性乙型肝炎感染是导致美国死亡的关键因素，研究人员分析了1999年至2014年间与美国国家死亡指数数据相关的国家健康和营养检查调查参与者，从而比较了慢性，既往和无乙型肝炎感染者最近一段时间内的风险以及死亡率的预测因素。该研究纳入了年龄在20岁或以上的接受乙型肝炎血清学检查的成年人，总计39,206人，其中包括192名（0.5％）的慢性患者和2,694名（6.9％）的先前乙型肝炎感染。大量饮酒和较高的丙氨酸转氨酶被认为是预测慢性感染全因死亡率的因素。总的来说，已经发现，即使有改良的治疗方法，也不能阻止慢性乙型肝炎感染成年人的死亡率高于未感染成年人的死亡率。通过检测慢性感染，在符合条件的患者中开始治疗以及调节疾病进展的辅助因子，可以确保提高生存率。

阅读有关《消化药理学和治疗学》的全文。