乙型肝炎表面抗原携带者的饮食习惯和肝癌风险：一项在中

StephenW

J Dig Dis. 2020 May 14. doi: 10.1111/1751-2980.12878. [Epub ahead of print]
Dietary habits and Risk of Hepatocellular Carcinoma among Hepatitis B Surface Antigen Carriers: A Prospective Cohort Study in China.
Cheng Xiao Y1,2, Chen YS3, Zi Jun G4, Zhang YH3, Xin X1,2, Tian T1,2, Wen Y1,2, Zhu J3, Song C1,2, Chen JG3,5, Zhi Bin H1,2.
Author information
Abstract
BACKGROUND:

China has the greatest number of Hepatitis B virus (HBV) infection people worldwide. In addition to nucleot(s)ide analogues drugs taking, regular inspection and appropriate exercise, reasonable diet is also an important measure to prevent HCC. A systematic evaluation of the relationship between dietary habits and the risk of HCC among the HBV carriers are still need.
METHODS:

We identified 3199 hepatitis B surface antigen (HBsAg) carriers aged 30 to 70 years in a prospective cohort in Qidong, China from 2007 to 2011. At baseline, all participants self-reported dietary habits through questionnaire interview. The follow-up checkup was performed every half a year to identify HCC cases until November 2017. Cox regression analysis and interaction analysis were performed to estimate the relative risks between HCC and baseline dietary habits.
RESULTS:

Among 3199 HBsAg-positive participants, 270 developed HCC (143.86/100000 person years [PYs]). When compared with participants rarely have consumption of garlic, the HCC risk for those have ≥1 times per week consumption of garlic decreased along with the frequency increased (HR = 1.00, 0.90 and 0.62 for rarely, 1-7 times per week, ≥7 times per week, respectively). Furthermore, this study found the synergistic effect between garlic and tea consumption on HCC risk (P = 0.039 for multiplicative interaction).
CONCLUSIONS:

It is necessary for HBsAg carriers paying attention to their dietary habits. Regular garlic consumption and tea drinking may reduce the HCC incidence for the HBsAg carriers. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
KEYWORDS:

HBV infection; HCC; dietary habits; garlic; prospective cohort

PMID:
    32407579
DOI:
    10.1111/1751-2980.12878

StephenW

J Dig Dis。 2020年5月14日。doi：10.1111 / 1751-2980.12878。 [Epub提前发布]
乙型肝炎表面抗原携带者的饮食习惯和肝癌风险：一项在中国的前瞻性队列研究。
程晓Y1,2，陈YS3，紫俊G4，张YH3，辛X1,2，田T1,2，温Y1,2，朱J3，宋C1,2，陈JG3，5，智斌H1,2。
作者信息
抽象
背景：

中国是全世界乙肝病毒感染人数最多的国家。除了服用类似核苷酸的药物，定期检查和适当运动外，合理饮食也是预防HCC的重要措施。仍需要对饮食习惯与HBV携带者中HCC风险之间关系的系统评价。
方法：

我们从2007年至2011年在中国启东市的前瞻性队列中确定了3199名年龄在30至70岁之间的乙型肝炎表面抗原（HBsAg）携带者。在基线时，所有参与者都通过问卷访问自我报告了饮食习惯。每半年进行一次随访检查，以鉴定HCC病例，直至2017年11月。进行Cox回归分析和交互作用分析以估计HCC与基线饮食习惯之间的相对风险。
结果：

在3199名HBsAg阳性参与者中，有270名发生了HCC（143.86 / 100000人年[PYs]）。与很少食用大蒜的参与者进行比较时，每周食用大蒜≥1次的人的HCC风险随频率增加而降低（HR分别为1.00、0.90和0.62，很少，每周1-7次，≥7每周一次）。此外，这项研究发现食用大蒜和茶对HCC风险具有协同作用（乘法相互作用P = 0.039）。
结论：

HBsAg携带者必须注意饮食习惯。定期食用大蒜和喝茶可以降低HBsAg携带者的HCC发生率。本文受版权保护。版权所有。

本文受版权保护。版权所有。
关键字：

乙肝病毒感染； HCC；饮食习惯；大蒜;预期队列

PMID：
32407579
DOI：
10.1111 / 1751-2980.12878