符合米兰标准的肝细胞癌患者进行微波消融或手术切除后的

StephenW

Oncol Lett. 2020 Jun;19(6):4066-4076. doi: 10.3892/ol.2020.11529. Epub 2020 Apr 10.
Survival analysis following microwave ablation or surgical resection in patients with hepatocellular carcinoma conforming to the Milan criteria.
Sun Q1,2,3,4,5, Shi J1,2,3,4,5, Ren C1,2,3,4,5, Du Z1,2,3,4,5, Shu G1,2,3,4,5, Wang Y1,2,3,4,5.
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Abstract

The aim of the present study was to compare the efficacy of microwave ablation (MWA) and surgical resection (RES) for the treatment of hepatocellular carcinoma (HCC) conforming to the Milan criteria and the associated short- and long-term survival rates. The baseline characteristics were obtained from 231 patients with HCC who met the Milan criteria. To compare the mortality rates between groups, survival analysis was conducted using the Kaplan-Meier method and the log-rank test. The factors associated with the survival rate were analyzed using Cox proportional hazard models. A total of 115 patients underwent RES, and 116 were treated with MWA. No significant differences were observed in the 1-, 3- and 5-year OS rates and the 1-year DFS rate between the two groups. The 7- and 10-year OS rates and the 3-, 5-, 7- and 10-year DFS rates of the RES group were significantly higher compared with those in the MWA group (P=0.004, P=0.002, P=0.003 and P=0.002, respectively). In addition, no marked differences were observed in the OS and DFS rates between the two groups of patients with solitary HCC lesions ≤3 cm (P=0.066 and P=0.056) and in the OS of those with solitary lesions of 3-5 cm (P=0.133); however the DFS of patients with single 3-5 cm HCC lesions in the RES group was notably higher compared with the MWA group (P=0.027). The Cox proportional hazard model revealed that age, hepatitis B and C virus infection, tumor size, number, platelet count and the type of treatment intervention were risk factors affecting the survival and recurrence in patients with HCC. These results suggested that RES may provide superior survival benefits compared with MWA for patients with HCC who meet the Milan criteria.

Copyright: © Sun et al.
KEYWORDS:

hepatocellular carcinoma; microwave ablation; surgical resection; survival analysis

PMID:
    32391107
PMCID:
    PMC7204632
DOI:
    10.3892/ol.2020.11529

StephenW

Oncol Lett。 2020年6月; 19（6）：4066-4076。 Doi：10.3892 / ol.2020.11529。 EPUB 2020年4月10日。
符合米兰标准的肝细胞癌患者进行微波消融或手术切除后的生存分析。
Sun Q1,2,3,4,5，Shi J1,2,3,4,5，Ren C1,2,3,4,5，Du Z1,2,3,4,5，Shu G1,2,3 ，4,5，Wang Y1,2,3,4,5。
作者信息
抽象

本研究的目的是比较符合米兰标准的微波消融（MWA）和手术切除（RES）治疗肝细胞癌（HCC）的疗效以及相关的短期和长期生存率。基线特征来自231例符合米兰标准的HCC患者。为了比较各组之间的死亡率，使用Kaplan-Meier方法和对数秩检验进行生存分析。使用Cox比例风险模型分析与存活率相关的因素。共有115例患者接受了RES治疗，其中116例接受了MWA治疗。两组之间的1年，3年和5年OS率和1年DFS率没有显着差异。与MWA组相比，RES组的7年和10年OS率以及3年，5年，7年和10年DFS率显着更高（P = 0.004，P = 0.002，P = 0.003和P = 0.002）。此外，在孤立的HCC病灶≤3 cm的两组患者中，OS和DFS率之间无明显差异（P = 0.066和P = 0.056），孤立病灶为3-5的患者的OS厘米（P = 0.133）;然而，与MWA组相比，RES组中单个3-5 cm HCC病变患者的DFS显着更高（P = 0.027）。 Cox比例风险模型显示，年龄，乙型和丙型肝炎病毒感染，肿瘤大小，数量，血小板计数和治疗干预类型是影响HCC患者生存和复发的危险因素。这些结果表明，与MWA相比，对于符合米兰标准的HCC患者，RES可能提供更好的生存获益。

版权：©Sun等。
关键字：

肝细胞癌；微波消融手术切除生存分析

PMID：
32391107
PMCID：
PMC7204632
DOI：
10.3892 / ol.2020.11529

StephenW

https://www.spandidos-publications.com/10.3892/ol.2020.11529

wumayken

很专业。是不是讲单个小于3厘米的肝癌，微波和手术的远近期生存率及复发率无明显差别，基本一样。但对于单个大于3厘米的肝癌，生存率和复发率是手术明显好于微波。