血小板计数在评估慢性乙型肝炎患者肝纤维化程度中的价值

StephenW

J Clin Lab Anal. 2020 May 4:e23270. doi: 10.1002/jcla.23270. [Epub ahead of print]
The value of platelet count in evaluating the degree of liver fibrosis in patients with chronic hepatitis B.
Zhong LK1, Zhang G1, Luo SY1, Yin W2, Song HY1.
Author information

1
    Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
2
    Department of Pathology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Abstract
OBJECTIVE:

To investigate the value of platelet count in evaluating the degree of liver fibrosis in patients with chronic hepatitis B (CHB).
METHODS:

A total of 158 CHB patients who underwent liver biopsy in our hospital were included, and the clinical characteristics of these patients were retrospectively analyzed. The diagnostic values of platelet count, aspartate aminotransferase-to-platelet ratio index (APRI), and the fibrosis index based on four factors (FIB-4) for significant fibrosis (F ≥ 2) and early cirrhosis (F = 4) stages in CHB patients were assessed by the use of receiver operating characteristic (ROC) analysis.
RESULTS:

The median (F0: 221.0; F1: 210.0; F2: 188.0; F3: 171.0; and F4: 155.5) and mean rank (F0: 120.4; F1: 100.1; F2: 82.2; F3: 67.9; and F4: 49.5) of platelet count decreased along the aggravation of fibrosis (F0-F4). The areas under the ROC curve for the platelet count in diagnosis of significant fibrosis stage was 0.70, which had no significant difference with FIB-4 (0.73) and APRI (0.68) in diagnostic efficacy (P = .428). The areas under the ROC curve of platelet count in diagnosis of early cirrhosis were 0.72, which had no significant difference with FIB-4 (0.76) and APRI (0.68) (P = .094).
CONCLUSION:

The platelet count, as a simple and non-invasive index, could evaluate the degree of liver fibrosis in CHB individuals. At the same time, the diagnostic efficiency of platelet count to evaluate the significant liver fibrosis and early cirrhosis is comparable to FIB-4 and APRI.

© 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.
KEYWORDS:

chronic hepatitis B; liver cirrhosis; liver fibrosis; platelet count

PMID:
    32363594
DOI:
    10.1002/jcla.23270

StephenW

J临床实验室肛门。 2020年5月4日：e23270。 doi：10.1002 / jcla.23270。 [Epub提前发布]
血小板计数在评估慢性乙型肝炎患者肝纤维化程度中的价值。
钟LK1，张G1，罗SY1，殷W2，宋HY1。
作者信息

1个
    广西壮族自治区人民医院消化内科，南宁。
2
    广西壮族自治区人民医院病理科，南宁。

抽象
目的：

目的探讨血小板计数在评估慢性乙型肝炎（CHB）患者肝纤维化程度中的价值。
方法：

纳入我院行肝活检的158例慢性乙型肝炎患者，并对其临床特点进行回顾性分析。血小板计数，天冬氨酸转氨酶与血小板之比指数（APRI）和基于四个因素的纤维化指数（FIB-4）对严重纤维化（F≥2）和肝硬化早期（F = 4）阶段的诊断价值通过使用接受者操作特征（ROC）分析评估CHB患者。
结果：

中位数（F0：221.0; F1：210.0; F2：188.0; F3：171.0;和F4：155.5）和平均排名（F0：120.4; F1：100.1; F2：82.2; F3：67.9;和F4：49.5）血小板计数随着纤维化的加剧而减少（F0-F4）。诊断显着纤维化分期时，ROC曲线下血小板计数的面积为0.70，与FIB-4（0.73）和APRI（0.68）的诊断功效无显着差异（P = .428）。诊断早期肝硬化的血小板计数的ROC曲线下面积为0.72，与FIB-4（0.76）和APRI（0.68）无显着差异（P = .094）。
结论：

血小板计数是一种简单且无创的指标，可以评估CHB患者肝纤维化的程度。同时，血小板计数对评估严重肝纤维化和早期肝硬化的诊断效率与FIB-4和APRI相当。

©2020作者。 Wiley Periodicals，Inc.出版的《临床实验室分析杂志》。
关键字：

慢性乙型肝炎肝硬化肝纤维化血小板计数

PMID：
    32363594
DOI：
    10.1002 / jcla.23270

StephenW

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcla.23270